ASIC1 Antibody HRP conjugated

Volume : 50 µg
Clone Number :
Aliases : ACCN2 antibody; ACCN2_HUMAN antibody; Acid sensing ion channel 1 antibody; Acid sensing ion channel 1a protein antibody; Acid sensing ion channel antibody; Acid-sensing ion channel 1 antibody; AI843610 antibody; Amiloride sensitive cation channel 2 neuronal antibody; Amiloride-sensitive cation channel 2 antibody; ASIC antibody; ASIC1 antibody; ASIC1A antibody; B530003N02Rik antibody; BNaC2 antibody; Brain sodium channel 2 antibody; Cation channel amiloride sensitive neuronal 2 antibody; hBNaC2 antibody; neuronal antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P78348
Immunogen : Recombinant Human Acid-sensing ion channel 1 protein (195-297AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracell µLar pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to mod µLate channel properties. Functions as a postsynaptic proton receptor that influences intracell µLar Ca(2+) concentration and calmod µLin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Mod µLates activity in the circuits underlying innate fear.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : HRP
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ASIC1
Research Areas : Neuroscience