ACTH (Adrenocorticotrophic Hormone) (C-Terminus) (CLIP/1449) , CF640R conjugate , 0.1mg / mL

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive , tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP , ACTH , alpha-MSH (Melanocyte Stimulating Hormone) , beta-MSH , gamma-MSH , CLIP (corticotropin-like intermediary peptide) , Lipotropin-beta , Lipotropin-gamma , beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells , B-cells , and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.