AMPK beta 2 antibody

Volume : 100 µg
Purification : Immunogen affinity purified
Form : liquid
Purity : 95% as determined by SDS-PAGE
Host : Rabbit
Clonality : polyclonal Ab
Clone ID :
Isotype : IgG
Storage : PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)
Background : The protein encoded by this gene is a reg µLatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cell µLar energy status. In response to cell µLar metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in reg µLating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive reg µLator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. M µLtiple alternatively spliced transcript variants have been found for this gene.
Immunogen : protein kinase, AMP-activated, beta 2 non-catalytic subunit
Aliases : AMPK beta 2, AMPK subunit beta 2, PRKAB2
Observed MW : 35 kDa
Uniprot ID : O43741
Reactivity : Human, Mouse, Rat
Application : ELISA, WB, IHC
Recommended dilution : WB : 1 : 500 - 1 : 2000; IHC : 1 : 50 - 1 : 200
Gene ID : 5565
Research Area : Signal Transduction, Metabolism