Virazole can be commonly prescribed as Copegus or Rebetol, and is often generically prescribed as ribavirin. Virazole is commonly used in the treatment of chronic hepatitis C.
Virazole is very dangerous for unborn babies and women who are pregnant or could become pregnant should not take this medication. Men with sexual partners who are pregnant should not take this medication as they can cause serious birth defects or death in babies through their partners.
Virazole is not appropriate for all patients and it is important that the prescribing physician take a thorough medical history before prescribing Virazole to a patient. Patients with a medical history which includes a hemoglobin disorder such as anemia or an autoimmune type of hepatitis can not take Virazole. Patients with a medical history which includes lung disease, breathing problems, cancer, diabetes, liver disease, kidney disease, heart disease, heart attack, high blood pressure, depression, suicide attempts, drug addiction, alcoholism, thyroid disorder, organ transplant, hepatitis B, HIV or AIDS, or sarcoidosis may not be able to tolerate taking Virazole or may require extra monitoring while undergoing drug therapy with this medication, depending on the condition and the severity of the condition.
There is a risk of side effects that may be experienced by patients taking Virazole, some of which might be serious. Serious side effects, drug interactions, and allergic reactions all require emergency medical attention. AN allergic reaction will present with symptoms which are likely to include hives, facial swelling, swelling of the lips, mouth, throat, or tongue, and difficulty breathing. Serious side effects may include symptoms such as serious depression, thoughts or actions involving self harm, fever, chills, body aches, flu symptoms, dark urine, pale colored stools, easy bruising, easy bleeding, pale skin, yellow skin or the whites of the eyes, confusion, unusual weakness, pain in the upper abdomen that spreads around to the back accompanied by fast heart rate, nausea, and vomiting, chest pain or a heaviness in the chest that may or may not involve the arm, difficulty breathing, general ill feelings with sweating and nausea, or significant mood changes.
Less serious side effects typically present as skin rash, itching, dry mouth, nausea, vomiting, disinterest in food, weight loss, skin rash, irritability, fatigue, joint pain, muscle discomfort, trouble concentrating, insomnia or other sleep problems, or a stuffy nose, and do not require more medical attention than simply reporting them to the prescribing physician. Often less serious side effects can become more manageable with a change in the daily dosage of Virazole.
Virazole should be taken as it has been prescribed, and patients should never alter their dose without checking with the physician. If a regularly scheduled dose is forgotten or missed, it should be taken when remembered unless it is almost time for the next scheduled dose in which case it should just be skipped. Taking doses too closely or taking more medication at one time than has been prescribed may result in an overdose. An overdose will require the patient to seek help at the nearest emergency room. An overdose may present with symptoms such as easy bruising, easy bleeding, difficulty in producing urine, chest pain or a heaviness of the chest that spreads down the arm accompanied by sweating, nausea, and a feeling of overall illness.
Other medications may interact with Virazole and patients should always consult with the physician or pharmacist before taking any new medications. This applied to prescription medications, over the counter medications, herbal remedies, and vitamin supplements. Medications with known interactions to Virazole include didanosine, stavudine, and zidovudine.
Virazole has the following structural formula:
• Molecular formula of virazole is C8H12N4O5
• Chemical IUPAC Name is 1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
• Molecular weight is 244.205 g/mol
• Virazole available : 200mg capsules, 40mg/ml solution
Generic name: Ribavirin
Brand name(s): Biopolymers, Copegus, Rebetol, Rebetron, Rebretron, Ribamide, Ribamidil, Ribamidyl, Ribasphere, Ribavirina, Ribavirine, Ribavirinum, Tribavirin, Varazid, Vilona, Viramid, Virazid
Review published on: 07 June 2007
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