Toradol is a brand name for ketorolac tromethamine, and is a non-steroidal anti-inflammatory drug, or NSAID. It is used for the short-term management of pain, and should not be used for more than five days altogether. It is often used to treat postoperative pain or other acute forms of pain. Toradol is usually given intravenously first, and then followed with oral tablets once the patient is able to take it.
Negative side effects increase the higher the dose of Toradol. Some of these side effects can include very serious ones such as gastrointestinal ulceration, bleeding or perforation, bleeding after surgery, kidney failure, liver failure, and allergic reactions--which include swelling of the face, lips or throat, difficulty breathing, or hives. Other side effects include abdominal pain, diarrhea or constipation, heartburn, gastrointestinal ulcers, nausea, stomach infection, or vomiting. You might also experience abnormal kidney function, drowsiness or fatigue, headaches, pain or infection at the site of injection, rashes, anemia, swelling, high blood pressure, itchy skin, ringing in the ears, dizziness, increased bleeding, red spots on the skin, or sweating. Other side effects may include fever, infections, congestive heart failure, irregular heart beat, hair loss, sensitivity to light, loss of appetite, dry mouth, excessive thirst, jaundice, rectal, gain or loss of weight, abnormal dreams or thinking, anxiety, confusion, depression or euphoria, inability to sleep, malaise, female infertility, asthma, cough, runny nose, increased need to urinate, conjunctivitis, psychosis, coma, pneumonia, or in extreme cases, even death. Toradol may cause serious cardiovascular effects, gastrointestinal discomfort, skin rashes, swelling, or serious allergic reaction.
Certain drugs should be used with extreme caution when taking Toradol. These include warfarin or other blood thinners, which may make the blood too thin. Toradol should not be administered with aspirin, since the protein binding is reduced and adverse side effects might be increased. When Toradol is given along with diuretics, you should be observed for signs of renal failure. Lithium does not process as efficiently when given along with Toradol and could build up to levels of toxicity. You should also be very careful when taking ACE-inhibitors for high blood pressure, as use with Toradol can decrease their effectiveness. Other substances that make the use of Toradol more dangerous include oral corticosteroids, anticoagulants, therapy with other NSAIDs, tobacco, or alcohol. Older people and those in generally poor health are at higher risk for serious side effects.
Toradol is in Pregnancy Category C, which means that it is generally safe for pregnant women and developing fetuses, but it should not be used in the third trimester of pregnancy, as it can impair the development of the baby’s heart. Toradol is excreted in human milk, so you should not use it while you are breast feeding, since it can inhibit the production of certain hormones in newborns. Toradol is not recommended for use by children under the age of seventeen, but may be considered safe for older patients if used with caution.
Toradol has the following structural formula:
• Molecular formula of toradol is C15H13NO3
• Chemical IUPAC Name is 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
• Molecular weight is 255.269 g/mol
• Toradol available : 10mg tablets
Generic name: Ketorolac
Brand name(s): Acular, Ketoralac, Ketorolaco, Ketorolacum
Review published on: 09 June 2008
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