Stavudine is a nucleoside analogue used mainly against HIV or human immunodeficiency virus. The United States Food and Drug Administration approved it for adult use in 1994 and for pediatric use in 1996. It is only the fourth drug of its kind to invade the market.
What Stavudine basically does is interfering new infections to come forth. Although it cannot kill the HIV outright, it can control viral infections that come through and through in patients infected by the virus. Usually, Stavudine is used in combination with other drugs to treat viral infections caused by HIV.
Before using Stavudine, you need to ensure that you can be safe with the drug. Discuss your medical history, allergies, current drug intake, and alcohol usage. Stavudine must be used carefully in patients with pancreatitis, nerve disease, kidney ailments, liver disorders, heart problems, and those who just underwent a major surgery.
The use of Stavudine in pregnant and lactating women poses risks of its own. If a pregnant or nursing mother may need to use this drug, make sure that it was discussed with a medical professional. Your doctor may give a go signal if it is proven that your benefits from the drug are still greater than the dangers.
Stavudine is also not safe to use with certain drugs. It is important, therefore, that you discuss your current drug intake including vitamins and supplements. This is to avoid serious drug interaction to occur.
Stavudine comes in capsule form of different strengths. The dosage depends on body weight and many other medical factors. Dosage adjustments are required for patients with renal impairment and hemodialysis patients.
Stavudine is usually given twice daily, every twelve hours. You must take your medication regularly to ensure that you get its full benefits. If you miss a dose, take it as soon as you remember it but not if it is too close to your next dose. In that case, you will need to discard that dose and continue with your regular dosing schedule. Taking a double dose is more dangerous than missing once. Take Stavudine at the same time each day so you will have an easier time remembering. It is very important that you take regular dosages of this drug upon doctor’s instructions.
Stavudine must be administered and used properly. If not, it can cause life-threatening conditions. Then again, like most drugs, it causes side effects, which is normal. Experiencing nausea, vomiting, diarrhea, and headache may just be because your body is not adjusted to the drug yet. However, they should disappear over a short time, otherwise they are cause for alarm. Stavudine can cause peripheral neuropathy, which can be disabling and lactic acidosis, which can be fatal.
Be very vigilant when using Stavudine. Keep track of your symptoms and report any thing indifferent to your doctor. You will need to submit yourself for regular check-ups and consultations while under this medication therapy. This is to ensure that the adverse effects do not overpower your benefits from the drug.
Stavudine has the following structural formula:
• Molecular formula of stavudine is C10H12N2O4
• Chemical IUPAC Name is 1-[5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
• Molecular weight is 224.213 g/mol
• Stavudine available : 15mg tablets, 20mg tablets, 30mg tablets and 40mg tablets
Brand name(s): Ddethd, Ddetyd, Estavudina, Sanilvudine, Stavudinum, Zerit, Zerit Xr, Zerut Xr
Review published on: 07 March 2009
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