Quinapril is a generic medication that also comes as the brand Accupril. It is used alone or in conjunction with other medications, especially diuretics, to treat hypertension, or high blood pressure. It is also given to patients who have had heart attacks to help them recover heart function, and it is used to treat heart failure. In some cases it is used as a preventative to keep certain high-risk people from having heart attacks or strokes in the first place. It belongs to a category of drugs called angiotestin-converting enzyme inhibitors, or ACE-inhibitors, and is administered in a capsule. Quinapril works by relaxing arterial muscles at the same time that it enlarges arteries, allowing an increase in blood flow when more blood is pumped through larger passageways.
Quinapril, like other medications, can cause side effects. You may experience headache, dizziness, weakness, fatigue, nausea and vomiting, low blood pressure, diarrhea, and upset stomach. Some people also develop a dry cough. These are normal reactions, but if they become severe or do not fade with time, you should contact your doctor. You may also experience loss of appetite, anxiety, sensitivity to light, memory loss, ringing in the ears, inability to sleep, depression, vision disturbances, dry mouth, taste disturbances, increased salivation, constipation, difficulty swallowing, or tremor. Other side effects are rare, but can be very serious. These include swelling of the face, throat, tongue, eyes, lips, hands or feet, hoarseness, difficulty breathing, difficulty swallowing, fever, sore throat, chills, lightheadedness, or fainting. If you experience any of these, be sure to tell your doctor right away. If you are taking other medications for diabetes, you may find that low blood sugar is manifested as sweating or shakiness.
Make sure your doctor knows if you are taking certain medications, both over-the-counter and prescription. These medications include aspirin and other non-steroidal anti-inflammatory drugs, diuretics, lithium, and potassium supplements. Other substances that might interact negatively with Quinapril include alcohol, oral diabetes drugs, and salt substitutes that contain potassium. You should also make sure your doctor knows if you have kidney or liver disease, if you are on a low salt diet or have high levels of potassium in your blood, or if you are taking any potassium-sparing diuretics. You may not be able to take Quinapril, or your doctor may wish to adjust your treatment, if you fall into any of those categories.
Quinapril is not to be taken during pregnancy; it can cause harm or even death to a developing fetus, especially in the second and third trimesters. If you discover that you are pregnant while you are taking Quinapril, you should contact your doctor as soon as possible and discontinue your Quinapril treatment. If you are taking Quinapril, you should also not breast feed, as small amount of this drug can accumulate in breast milk and be passed to a nursing child. Studies have shown that Quinapril can cause irreversible kidney damage in young laboratory animals, so it is not recommended for use in children.
Quinapril has the following structural formula:
• Molecular formula of quinapril is C25H30N2O5
• Chemical IUPAC Name is 2-[2-(1-ethoxycarbonyl-3-phenyl-propyl)aminopropanoyl]-1,2,3,4- tetrahydroisoquinoline-3-carboxylic acid
• Molecular weight is 438.516 g/mol
• Quinapril available : 5mg tablets, 10mg tablets, 20mg tablets, 40mg tablets
Brand name(s): Accupril, Accuprin, Accupro, Acequin, Acuitel, Korec, Quinaprilum, Quinazil
Review published on: 31 March 2008
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