Propranolol belongs to a class of medications called beta-blockers. Its chief use is as a blood pressure medication, but it is also used to prevent migraines in children. It has several other uses as well, including the treatment of chest pains, irregular heartbeat, heart attacks, control of tremors associated with anxiety or hyperthyroidism, and an experimental use as a treatment for PTSD, or post-traumatic stress disorder. It is sometimes used by performers to prevent stage fright, and can be used to lower portal vein pressure for those with portal hypertension. There is also research to indicate that it may be a useful agent in the treatment of malaria. Propranolol is administered in tablets or capsules.
Propranolol can have some serious side effects. These may include congestive heart failure, low blood pressure, tingling or numbness in your hands, arterial insufficiency, spots on the skin due to underlying blood clots, dizziness, depression, insomnia, lethargy, weakness, fatigue, catatonia, disturbances in your vision, hallucinations, vivid dreams, disorientation, short-term loss of memory, and mood swings, though some of these effects may be dose-related and will go away with a lower dosage of Propranolol. You may experience nausea and vomiting, stomach cramps, diarrhea or constipation, colitis, respiratory problems such as bronchospasm, skin reactions such as Stevens-Johnson syndrome, dry eyes, hair loss, epidermal necrolysis, exfoliative dermatitis, urticaria, or psoriasis-like rashes. Your immune system may react by developing lupus, and your blood system may develop the rare conditions of agranulocytosis or purpura. Other possible side effects may include impotence, Peyronie’s disease, or allergic reactions such as swollen throat, rash, fever, or difficulty breathing. In some people, angina pectoris, or chest pains, can actually become worse instead of better, especially when Propranolol is discontinued suddenly. Since angina is one symptom of heart disease, you should quit taking it gradually, and make sure to report to your doctor if you have any serious chest pains while taking it.
If you are taking other medications, you should be very carefully observed while you are taking Propranolol along with them. This is especially true for heart medications, such as antiarrhythmics, beta-blockers, digitalis, calcium channel blockers, ACE-inhibitors, reserpine, intropic agents, isoproterenol and dobutamine. Other medications can react with Propranolol, including NSAIDs, or non-steroidal anti-inflammatory drugs, antidepressants, anesthetics, wWarfarin or other blood thinners, neuroleptic drugs, thyroxine, and alcohol. Make sure your doctor knows if you are taking any of these before you begin taking Propranolol.
Propranolol is in Pregnancy Category C, which means that it is not known whether it can harm an unborn baby or disrupt a pregnancy. There have not been adequate studies on pregnant women to determine this. However, some mothers who took Propranolol during pregnancy have had babies who displayed problems. The connection is not clear, so it is recommended that you and your doctor determine whether the benefits of Propranolol outweigh the risk. Propranolol is excreted in breast milk, so caution should be used if you are nursing or planning to nurse your baby.
Propranolol has the following structural formula:
• Molecular formula of propranolol is C16H21NO2
• Chemical IUPAC Name is 1-(1-methylethylamino)-3-naphthalen-1-yloxy-propan-2-ol
• Molecular weight is 259.343 g/mol
• Propranolol available : 10mg tablets, 20mg tablets, 40mg tablets, 80mg tablets
Brand name(s): Angilol, Apsolol, Avlocardyl, Bedranol, Beprane, Berkolol, Betachron, Betalong, Cardinol, Caridolol, Corpendol, Deralin, Dociton, Duranol, Efektolol, Elbrol, Etalong, Euprovasin, Frekven, Inderal, Inderide, Indobloc, Innopran XL, Intermigran, Kemi S, Obsidan, Oposim, Propanalol, Propanix, Propanolol, Prophylux, Propranur, Proprasylyt, Pylapron, Rapynogen, Reducor, Sagittol, Servanolol, Sloprolol, Sumial, Tesnol
Review published on: 02 June 2008
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