Panretyn is an antineoplastic agent developed by Ligand Pharmaceurinary tract infectioncals and is also known as Panretin or Toctino. It is a first-generation retinoid that Ligand gained Food and Drug Administration approval of in February 1999.
As "Panretin", it is a gel used to treat people with skin lesions and acquired immunodeficiency syndrome-related Kaposi's sarcoma, while as "Toctino", it is a capsule used to treat patients with chronic hand eczema. Panretyn is chemically related to Vitamin A and is a yellowish powder with a molecular formula of C20H28O2 and a molecular weight of 300.44.
Panretin, should be applied two times a day to cutaneous KS lesions during the initial stages of treatment. You may apply the gel liberally in order to cover the lesion with a generous coating, and then allow it to dry for three to five minutes before covering it with clothing. Avoid getting the gel on or near mucosal surfaces (nose, mouth, and eyes) of your body.
As for the Toctino capsule, it must be taken after every meal and swallowed whole. Dosage ranges from 10 milligrams to 30 milligrams once every day for twelve weeks (three months) to twenty-four weeks (six months) depending on the patient's condition. Consult your doctor immediately if you are having difficulty with the medication.
Panretin's known side effects include itching, a burning sensation, and mild redness of the skin. You must also notify your doctor immediately for these less common side effects: cracking or oozing skin, blistering, stinging or tingling skin, peeling, swelling, rash, and severe redness. It's rare for patients under Panretin treatment to get sunburn, but if you do get it, you must consult your physician as soon as possible.
As for the known side effects of the Toctino capsule, you might get eye problems, eye inflammation or madras eye, thyroid problems, decreased clotting or other blood cell disorders, flushing, muscle and arthralgia, liver problems, dry skin, inflamed skin, and baldness. Ask a pharmacist for eye drops if you need to continue Toctino treatment despite its eye-related side effects. It's recommended for you to wear glasses instead of contacts while undergoing Toctino therapy.
Before taking Panretin, you must report to your healthcare specialist your medical history, including occurrences of tumors like lymphoma, skin conditions, and allergies. It has been known to induce sunburn, so you should wear sunscreen and protective clothing while taking Panretin. Also, keep the treated areas of your skin away from sunlamps. Consult your pharmacist for any further queries and concerns.
Avoid taking Toctino if you are currently taking tetracycline (a type of antibiotic); if you are allergic to Panretyn, other ingredients of Toctino, or any other retinoids such as isotretinoin; if you have very high levels of Vitamin A in your body; if you have untreated thyroid illness; if you have high blood fats such as raised triglycerides or high cholesterol; if you have severe kidney illness; or if you have liver illness.
Expecting mothers should avoid using this medication (Panretin or Toctino) during pregnancy because it may harm your unborn baby once it's absorbed into your bloodstream. It is not known whether this medication passes into breast milk, so it's not advised for breastfeeding mothers to use this medication. Notify your doctor before using this medication while pregnant or breastfeeding.
Panretyn has the following structural formula:
• Molecular formula of panretyn is C20H28O2
• Chemical IUPAC Name is 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-nona-2,4,6,8-tetraenoic acid
• Molecular weight is 300.435 g/mol
Generic name: Alitretinoin
Brand name(s): Avita, Beta-retinoic acid, Panretin, Panrexin, Renova, Retin-A, Retinoate, Retinoic acid, Trans-Retinoic acid, Tretinoin, Vesanoid, Vitamin A acid
Review published on: 31 December 1969
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