Oxsoralen is a brand name for methoxsalen, a substance which occurs naturally and is prescribed in capsules for the treatment of severe, recalcitrant, disabling psoriasis. An hour to an hour and a half after taking the Oxsoralen capsule, you are then exposed to long wave ultraviolet radiation. You may be exposed to differing quantities of ultraviolent light depending on whether your skin always burns and never tans, always burns but sometimes tans, sometimes burns but always tans, or never burns but always tans.
When you are receiving Oxsoralen in conjunction with ultraviolet radiation, there are certain safety precautions you must take. Your facility must have protection from electrical hazards, with all units grounded properly. You must not be able to come into contact with any bare lamps. There should be hand holds and hand rails available. There should be a window behind which the technician can view the patient without risking exposure to radiation. The patient should be able to open the doors of the treatment room from the inside, there should be a non-skid floor, and the temperature should be comfortable. The radiation device should be equipped with a timer that automatically shuts off the exposure, the patient should have an alarm button within reach for emergencies, and all radioactive devices must be properly labeled with warning signs indicating the danger of radiation exposure.
The most common side effect of Oxsoralen alone is nausea, so it is recommended that you take your capsule with milk or food. Other side effects of Oxsoralen alone include nervousness, sleeplessness, and depression. When Oxsoralen is combined with ultraviolet therapy, side effects include itchy skin, red or inflamed skin, swelling, dizziness, headaches, flu-like symptoms, depression, hives, gastrointestinal difficulties, leg cramps, low blood pressure, and worsening of psoriasis. You may also experience burning on your skin due to exposure to the ultraviolet rays. In addition, prolonged radiation exposure can cause cancer, so you should make sure you are being examined for carcinomas both during and after your treatments.
Some people should not take Oxsoralen. Those with a history of light sensitive diseases, such as lupus, porphyria, or albinism, should not take this treatment. If you have a history of melanoma, or if you currently have ssquamous cell carcinoma, you should not take it. And if you have aphakia, the loss of a corneal lens, you should not undergo this treatment as it could further damage your eyes.
Oxsoralen is in Pregnancy Category C, which means that it is not known whether it will cause harm to a fetus or complicate a pregnancy. It should only be given to women of child bearing capacity if it is clearly needed. It is also not known whether Oxsoralen is excreted in breast milk, so you should consult your doctor if you plan to nurse a child. Radiation therapy, however, may cause damage to a developing fetus, and should be avoided during a pregnancy. It has not been established whether Oxsoralen is safe for children, so pediatric use is not recommended.
Oxsoralen has the following structural formula:
• Molecular formula of oxsoralen is C12H8O4
• Molecular weight is 216.19 g/mol
• Oxsoralen available : 10mg capsules
Generic name: Methoxsalen
Brand name(s): Ammodin, Ammoidin, Meladinin, Meladinine, Meladoxen, Meloxine, Methoxa-Dome, Methoxaten, New-Meladinin, Oxoralen, Oxypsoralen, Puvalen, Puvamet, Uvadex, Xanthotoxin, Xanthotoxine, Xanthoxin, Zanthotoxin
Review published on: 14 February 2008
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