Mupirocin is an antibiotic that is mainly used topically—that is, on the skin—for the treatment of dermatological conditions like impetigo, a disease of the skin caused by the bacteria Staphylococcus aureus, Sterptococcus pyogenes, and beta-hemolytic streptococcus. It can also be administered inside the nose by patients and some people who work in healthcare centers to treat intranasal and methicillin-resistant Staphylococcus aureus (MRSA).
Mupirocin works differently from other antibiotics that work on either the walls of bacteria or bacterial DNA. That is, this medication instead blocks the activity of an enzyme called isoleucyl tRNA synthetase within the bacteria, which hampers the bacteria's ability to make proteins. Without this crucial ability, the bacteria tend to die and your bacterial infection is thusly treated.
Mupirocin cream products should only be used on the skin. Conversely, mupirocin nasal products should only be used on the inside of your nose. Clean and dry the affected area first before applying the cream. Administer a small, pea-sized amount of ointment to the area for about three times a day or as directed by your physician or dermatologist. You may cover the treated area with a bandage for maximum antibiotic benefit. Use the cream regularly in order to get the most out of it.
Continue treatment for the full amount of time prescribed, no more and no less. Be warned that early discontinuation of mupirocin therapy may allow remaining bacteria to grow and result in a relapse of the infection. Avoid using the cream around your mouth, nose, eyes, or large areas of broken or damaged skin unless otherwise instructed by your doctor. Lastly, consult your doctor if your infection does not improve within three to five days.
Before beginning mupirocin therapy, inform your healthcare specialist, dermatologist, or pharmacist of all the nonprescription, prescription, and herbal product you're using of have used, especially of chloramphenicol. As briefly mentioned earlier, you must not start or stop using the medication without prior doctor or pharmacist approval. On the other hand, there are no known drug interactions with mupirocin nasal ointment. However, it should still not be used simultaneously with other drugs that are applied inside the nose.
Furthermore, there are no sufficient studies and examinations in regards to mupirocin's effects in pregnant women. What little is known about the drug is shown in studies in animals that suggest no important or dire effects of mupirocin usage on the unborn child. Therefore, mupirocin can be used in pregnancy if your doctor feels that it is necessary or if the unknown risks are outweighed by your need to take the medication in the first place. This drug should only be used when clearly required during pregnancy.
There is also no adequate information on the safeness of mupirocin treatment in nursing infants. More to the point, it is currently unknown if any of the tiny amount of the drug that is absorbed from the skin into the blood of the mother concentrates in breast milk. As such, it is recommended that mothers don't nurse while undergoing treatment with this antibiotic agent.
Before you use this medicine, inform your pharmacist or doctor if you are allergic to it, polyethylene glycol, or if you have any other allergies. On that note, you must tell your designated healthcare specialist your medical history, especially if you've suffered or are currently suffering from kidney disease.
Until your body adjusts to the drug, first-time mupirocin cream usage may produce the following side effects: pain, itching, stinging, or burning of the skin. If any of these symptoms continue or worsen, you must consult your pharmacist or doctor as soon as possible.
Moreover, you must seek energy medical assistance immediately if severe itching or a rash occurs. Prolonged use of this topical antibiotic may cause a new infection like fungal infection to develop. As for the nasal ointment version of mupirocin, common side effects include pharyngitis, taste perversion, rhinitis, and headache.
Mupirocin has the following structural formula:
• Molecular formula of mupirocin is C26H44O8
• Chemical IUPAC Name is 13-[3,4-dihydroxy-5-[[3-(3-hydroxybutan-2-yl)oxiran-2-yl]methyl]oxan-2-yl]- 12-methyl-10-oxo-tridec-11-enoic acid
• Molecular weight is 484.623 g/mol
Brand name(s): Bactoderm, Bactroban, Centany, Mupirocine, Turixin
Review published on: 24 April 2009
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