Mantadine is a manmade anti-viral medication that hampers the duplication of a virus within cells and was approved by the FDA in 1996. Currently, it is not known how the medication works in treating Parkinson's disease, just that it does work. The effects may be connected to the medicine’s ability to amplify the effects of dopamine, a neurotransmitter in the brain whose function is usually lacking in patients with Parkinson's disease.
Anyone suffering from Parkinson's disease or who wants to prevent the spread of a viral infection (particularly influenza) is a candidate for this medicine.
To prevent viral infection, the medication should be administered prior to exposure to the virus just as with a vaccine. Not a practical treatment for most viral infections, it has been used to prevent Influenza A during flu season. Even when given a day or two after the onset of flu symptoms, it is effective in decreasing the severity of flu symptoms. Mantadine is also being used to improve the symptoms of Parkinson's disease.
This medication is typically taken once or twice daily with or without food. If it causes an upset stomach, the patient should take the next dose with food. When treating influenza, this medicine should be taken within 24 to 48 hours after the first flu symptoms appear and should be continued 24 to 48 hours after the disappearance of the flu symptoms or at least 10 days total. Elderly persons and those with reduced kidney function may need lower or less frequent doses. Consult your doctor for additional information.
Common known side effects include vomiting, nausea, nervousness, inability to sleep, loss of coordination, and dizziness. Roughly one in twenty people are reported to suffer from these side effects and the side effects typically emerge several days or even just a few hours after treatment begins. Less common side effects include discoloration of the eye, loss of appetite, constipation, diarrhea, slurred speech, amnesia, weakness, drowsiness, hallucinations, confusion, depression, nightmares, irritability, and headache. Seek immediate medical attention if you experience any of these symptoms.
Levodopa is more effective than Mantadine in treating Parkinson's disease, but when taken together, the patient will see additional benefits. Mantadine can alter the effects of alcohol and other sedatives such as the tricyclic class of antidepressants (Norpamin, Tofranil, and Elavil), the benzodiazepine class of anti-anxiety drugs (Ambien, Valium, Xanax, Klonopin, and Ativan), opiate agonists (Codeine, Vicodin, Dilaudid, and Percocet), certain antihypertensive medications (Catapres and Inderal), and certain antihistamines (Tavist, Atarax, Vistaril, and Benadryl). Combining Mantadine with any of the above medications may cause dizziness upon standing, fainting, lightheadedness, or confusion for the patient.
Mantadine enhances the effects of dopamine in the brain, so other medications that block the effects of dopamine should be avoided while taking it for Parkinson's disease. Medicines that should be avoided include phenothaizines like Mellaril (thioridazine) and Stelazine (triflupromazine), Haldol (halperidol), and Reglan (metoclopramide). Using diuretics hydrochlorothiazide or Dyazide/Maxzide (triamterene) with Mantadine can impede the kidney's ability to purge Mantadine from your body. This can lead to increased levels of the medicine in your blood and can increase your risk for side effects.
Currently, it is not known if Mantadine is safe for pregnant women or their unborn babies. Consult your doctor in order to determine whether or not Mantadine's benefits to the pregnant woman outweigh its risks and disadvantages. Also, this medication has been proven to pass into breast milk in low concentrations. Even though it is not known how toxic it is to infants, nursing mothers are strongly discouraged from breastfeeding their babies while taking Mantadine. Consult with your doctor for more information and recommendations.
Mantadine has the following structural formula:
• Molecular formula of mantadine is C10H17N
• Chemical IUPAC Name is adamantan-1-amine
• Molecular weight is 151.249 g/mol
• Mantadine available : 100mg tablets
Generic name: Amantadine
Brand name(s): Adamantamine, Adamantanamine, Adamantylamine, Adekin, Amantidine, Aminoadamantane, Endantadine, Symadine, Symmetrel
Review published on: 25 December 2009
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