Isosorbide mononitrate is the generic name for a medication that also goes under the brand names ISMO, Monoket, and Imdur. It belongs to a class of drugs known as nitrates, and is used to prevent angina and reduce the strain on the heart experienced by people with heart disease. Isosorbide mononitrate works by relaxing and widening the blood vessels, allowing blood to flow more easily. It is not meant to treat chest pains once they start, but when taken according to directions, it can prevent them from happening. Isosorbide mononitrate should be taken twice a day, with doses seven hours apart, or in a single extended-release tablet.
Isosorbide mononitrate, like any medication, can cause side effects in some people. These can include headache, tiredness or sleep disturbances, dizziness, lightheadedness, nausea or vomiting, gastrointestinal disturbances, high or low blood pressure, anxiety, back pain, fever, flu-like symptoms, and loss of appetite, especially as your body gets used to having this drug in its system. Since headache is often a sign that the medication is working as it should, you can treat it with pain reliever and experience no adverse effects.
Some side effects are rare but serious, and should be reported to your doctor immediately. These can include more severe or more frequent chest pain, flushing, a heart beat that is slower or faster than usual, or fainting. In some people Isosorbide mononitrate can provoke an allergic reaction. This is unusual, but you should call your doctor immediately if you experience a rash or hives, itching, swelling, severe dizziness, or difficulty breathing. Isosorbide mononitrate can make you dizzy, so you should avoid drinking alcohol and getting too hot, both of which can aggravate dizziness.
There are some people who should not take Isosorbide mononitrate. If you are allergic to nitrates such as nitroglycerin, or to nitrites, you should inform your doctor. If you have had a recent head injury resulting in increased intracranial pressure, severe anemia, certain severe stomach or abdominal diseases, low blood pressure, dehydration, heart conditions such as cardiomyopathy or a recent heart attack, exposure to nitrates in your job, or an overactive thyroid, you should not take Isosorbide mononitrate. If you are taking sildenafil, which is Viagra or other therapies for erectile dysfunction, calcium channel blockers, calcium antagonists, or propranolol, you should not take Isosorbide mononitrate.
Isosorbide mononitrate should be used very carefully when given to those over the age of sixty-five, since this age group may be more likely to experience problematic side effects. They are especially at risk for dizziness and lightheadedness. It has not been tested for children and is not recommended for their use. Animal tests indicate that it is not safe to take Isosorbide mononitrate in pregnancy; it is recommended that it only be given during pregnancy if it is clearly needed. It is also not known whether it passes into breast milk, so you should discuss it with your doctor if you are breast feeding or planning to breast feed your baby.
Isosorbide mononitrate has the following structural formula:
• Molecular formula of isosorbide mononitrate is C6H9NO6
• Chemical IUPAC Name is 8-nitrooxy-2,6-dioxabicyclo[3.3.0]octan-4-ol
• Molecular weight is 191.139 g/mol
• Isosorbide mononitrate available : 10mg tablets, 20mg tablets
Generic name: Isosorbide mononitrate
Brand name(s): Conpin, Corangin, Duride, Edistol, Elan, Elantan, Epicordin, Etimonis, Fem-Mono, Imazin, Imdur, Imdur Durules, Imodur, Imtrate, Ismexin, Ismo, Ismotic, Ismox, Isomon, Isomonat, Isomonit, Isosorbidi Mononitras, Isotrate, Iturol, Medocor, Monicor, Monis, Monisid, Monit, Monizid, Mono Corax, Mono Mack, Monocedocard, Monoclair, Monodur Durules, Monoket, Monolong, Mononit, Mononitrato de Isosorbida, Monopront, Monosigma, Monosorb, Monosorbitrate, Monosordil, Monotrate, Multitab, Nitex, Nitramin, Olicard, Olicardin, Orasorbil, Pentacard, Percorina, Pertil, Plodin, Promocard, Sigacora, Sorbimon, Titarane, Turimonit, Uniket, Vasdilat, Vasotrate
Review published on: 19 January 2008
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