Idarubicin belongs to 2 classes of drugs known as antimetabolites and antitumor antibiotics and is a chemotherapy drug. This drug is given as treatment for some types and cancers and leukemia.
This works by counteracting the main actions of cancer. Since cancer is mainly classified by cell division, this process which cancerous cells would go through to multiply, idarubicin stops those cancerous cells from dividing by damaging the DNA and RNA present in those cells. Once those cells would not be able to divide, they would perish. This in turn would cause the tumor to shrink.
This drug is mainly given to patients with conditions such as acute lymphoblastic leukemia, acute myelogenous leukemia, myelodysplastic syndromes and chronic myelogenous leukemia however; the doctor may prescribe this drug as a cure for other conditions.
Before taking idarubicin, the doctor has to be aware of some details about the patient’s medical history particularly if a patient is pregnant or lactating, suffers from kidney, liver or heart problems, has an infection, allergies to any medicine, suffer from blood disorders, has plans of having children in the future, has any blood disorders and if taking any other drugs, vitamins and supplements other than idarubicin.
Idarucibin should only be taken as directed by the doctor. The amount of idarubicin that would be prescribed would depend on several factors including the patient’s height and weight .To learn more about the drug, read the leaflet of which this drug would come with.
Idarucibin can either be ingested as a capsule that would come in either 5mg or 25mg, through and intravenous injection. When taking idarubicin capsules, it is very important that the patient should drink plenty of water afterwards. If the process would involve the intravenous injection, this has to be handled by a well-trained nurse as leaking of the solution outside the veins would cause a lot of serious problems. If the patient should encounter any discomfort such as reddening right after receiving idarubicin through IV, medical help should be sought immediately.
Different cases would bring about different side effects especially if a patient is taking other chemotherapy drugs aside from idarubicin. Some patients may experience a lot of discomforting side effects, while others might not experience any.
Some of the most common side effects of idarubicin, which is experienced by 30% of all people who take the drug would be pain on the area where the drug was injected and low blood counts as these may decrease temporarily after having idarubicin in a patient’s system.
Other common side effects would be change of color in urine, mouth sores which would commonly appear after the first week, diarrhea, nausea, and hair loss.
Less common side effects of this drug would be headache, fever, discoloration or darkening in the skin or the nails, heart rhythm abnormalities and infertility.
Before taking idarubicin, the doctor should know if the patient is taking any other substances aside from idarubicin including vitamins, minerals, supplements and herbal products. Aspirin and aspirin containing products are not to be taken along with idarubicin unless permitted by the doctor.
Women who are pregnant and lactating as well as men and women who plan to have children in the future should discuss issues with their doctors. Generally, idarubicin is not recommended to be taken for anyone who would fit the categories above.
Idarubicin has the following structural formula:
• Molecular formula of idarubicin is C26H27NO9
• Chemical IUPAC Name is 9-acetyl-7-(4-amino-5-hydroxy-6-methyl-tetrahydropyran-2-yl)oxy-6,9,11- trihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione
• Molecular weight is 497.494 g/mol
Brand name(s): Idamycin, Idarubicina, Idarubicine, Idarubicinum
Review published on: 24 August 2009
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