Glipizide was originally made available to the public in 1984. It is manufactured in the USA by Pfizer. It is sold under the generic name, Glucotrol. Glipizide can be taken orally. In most cases, it is taken once a day, half an hour before eating breakfast.
Glipizide is prescribed to people who have Type 2 Diabetes. This form of diabetes is a condition wherein the patient’s body is unable to digest insulin normally. Because insulin is not maximized, the body is then unable to control the blood’s sugar content.
Basically, Glipizide helps Type 2 Diabetes patients decrease their blood sugar. Glipizide functions by stimulating the pancreas, causing it to increase insulin production. With increased production of insulin, the patient will be able to manage sugar levels much more effectively.
However, people must take caution. Glipizide is only applicable for Type 2 diabetes where insulin is insufficient. It should not be prescribed for people with Type 1 diabetes where the body produces no insulin at all.
Before you start taking Glipizide, it is very important that you inform your doctor of other medications you are taking. More specifically, inform your doctor if you are taking antibiotics. Since Glipizide works by lowering sugar in the blood, make sure you tell your doctor if you are taking anticoagulants or blood thinners like, dexamethasone and warfarin.
Diuretics or water pills may also interact negatively with Glipizide. Other medications like estrogens, MAO inhibitors or antidepressants can also trigger negative effects when taken along with Glipizide. Patients who are taking anti-tuberculosis medication like isoniazid or are currently under medication for cardio-vascular diseases should also ask their doctor on whether Glipizide is compatible with their current medications.
People with Type 2 diabetes who are currently using some form of oral contraceptive or are regularly drinking vitamins should also be careful since these contraceptives and vitamins may not work well with Glipizide’s functions.
Also, alcohol can cause your blood sugar to decrease. So, do contact your doctor and ask about the safe amount of alcohol intake while on Glipizide.
Since Glipizide functions by affecting the body’s insulin production and eventually, the blood’s sugar content. By altering your blood’s sugar levels, Glipizde can cause you to develop either hypoglycemia or hyperglycemia. These conditions refer to your blood’s sugar levels and it’s important to know whether you have developed these.
Depending on your body’s reaction to Glipizide, you can experience side effects low blood sugar or hypoglycemia. Under this condition, you may feel lightheadedness, excessive sweating, nervousness, fatigue and hunger. You may also notice shakiness and clumsiness in your movements, along with a tingling sensation in your mouth. Your skin may also appear pale.
Hypoglycemia can easily be addressed by introducing high-sugar foods in your diet. Your doctor may ask you to drink fruit juices or eat candies. However, if left untreated, hypoglycemia can lead to very serious symptoms. If you experience loss of consciousness, confusion or seizures, contact your doctor immediately.
Meanwhile, your body can also react in the opposite way and this can lead you to high blood sugar or hyperglycemia. This may lead you to experience extreme thirst and hunger. You may also urinate more often than usual. Your vision may be blurred and you may also feel extremely weak. If not addressed immediately, hyperglycemia can lead to a much more condition called, diabetes ketoacidosis. If you have this condition you may experience the following symptoms: dry mouth, fruit-smelling breath, upset stomach, decreased consciousness and vomiting. Once you experience these symptoms, inform your doctor immediately.
Taking Glipizide can also cause other side effects. IT can affect the skin and cause the patient to develop rashes. The patient may also feel itching. Glipizide can also cause the skin to be more sensitive. This may exaggerate the effects of sunburn on the skin.
When taking Glipizide, the patient may also observe sore throat, yellowing of the skin or eyes and some bruising or bleeding. The patient may also notice having light-colored stool and a darker urine.
Glipizide has the following structural formula:
• Molecular formula of glipizide is C21H27N5O4S
• Chemical IUPAC Name is N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-pyridine-2-carboxamide
• Molecular weight is 444.548 g/mol
• Glipizide available : 5mg tablets, 10mg tablets
Brand name(s): Aldiab, Apamid, Digrin, Dipazide, Glibenese, Glibetin, Glican, Glide, Glidiab, Glipid, Glipizida, Glipizidum, Gluco-Rite, Glucolip, Glucotrol, Glucozide, Glupitel, Glupizide, Glyde, Glydiazinamide, Melizide, Metaglip, Mindiab, Minidab, Minidiab, Minodiab, Napizide, Ozidia, Sucrazide
Review published on: 13 May 2008
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