Marketed under the name Myambutol, Ethambutol is a drug given as treatment to tuberculosis (TB) patients.
Ethambutamol is never the lone treatment for tuberculosis. It is usually taken together with other dmedicines.
It is sold under the name "Myambutol". Scientifically, this medicine is classified under a bacteriostatic antimycobacterial drugs.
Ethambutol works by formation of cell walls in the TB bacilli. This makes the cell wall of the bacteria easily permeable.
More specifically, it acts by ihibiting the production of arabinogalactan and arabinoman. This is done by discouraging the release of the decaprenil - R - arabinose activity. Later, mycolic acids will attach to the wall of the bacterial cell. It will create a mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. This will make the bacterial cell highly permeable. Ethambutol’s effectiveness lies in its ability to exercise its bacteriostatic effect on many forms of tuberculostatics and tubeculous bacteria.
It is usually absorbed quickly through the gastrointestinal tract. After that, it is efficiently distributed to the tissues. However, 50% of it goes our through the urine, maintaining the same structure as when it was absorbed by the body.
Ethambutol comes as a tablet to take by mouth. It usually is taken once a day in the morning. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ethambutol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Ethambutol is taken orally. Usually, it is taken once a day, preferably in the morning. Ethambutol may upset the stomach so the patient must east before he or she takes the medicine.
Before beginning with your ethambutol treatment, there are certain conditions that you must consult with your doctor first. First of all, you must inquire to your doctor about how you can find out or if you have any history of allergic reactions to Ethambutol. Also, if you are taking vitamins or antacids, inform your physician. These subatances tend to make ethambutols’ effects weaker.
Also, it would be wise to inform your doctor of any other pre-existing condition. And if you are pregnant or I planning to be, tell your doctor, too. This way, he can tell you whether the treatment will cause negative effects in the fetus.
Naturally, ethambutol also carries certain side effects. You may lose appetite, experience stomach pain, and vomiting. However, there are also side effects that are much severe and may be indicative of other illnesses. These severe side effects include the blurring of vision, color blindess, changes in vision and even, skin rashes.
It can also cause peripheral neuropathy, a condition where a certain bodily function is impaired due to the damage of a certain type of nerve. The patient may also develop Optic neuritis. In optic neuritis, the patient may experience partial loss of vision as a result of swollen optic nerves. The patient may also develop joint pain as part of an allergic reaction to Ethambutol.
Ethambutol has the following structural formula:
• Molecular formula of ethambutol is C10H24N2O2
• Chemical IUPAC Name is 2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol
• Molecular weight is 204.31 g/mol
• Ethambutol available : 200mg tablets, 400mg tablets, 600mg tablets, 800mg tablets
Brand name(s): Aethambutolum, Dadibutol, Diambutol, Etambutol, Etambutolo, Ethambutolum, Etibi, Myambutol, Tibutol
Review published on: 05 May 2008
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