Ergoloid mesylate, or co-dergocrine mesylate are drugs that are mixtures of methanesulfonate salts of three ergot alkaloids that have been dehydrogenated (dihydroergocornine, dihydroergocristine, and alpha and beta dihydroergocryptine).
Many consider the mechanism of action of Ergoloid mesylate unclear. It is known to stimulate serotogenic and dopaminergic receptors, and at the same time block adrenoreceptors, specifically alpha-adrenoreceptors. Ergoloid mesylate have been considered as a nootropic or memory-enhancing drug. Recent studies have shown that the major effect of the drug has been the modulation of neurotransmission of synapses as opposed to the initially accepted idea of increasing blood flow in the brain.
Ergoloid mesylate have been indicated to treat patients afflicted with dementia, and as well as cognitive impairment related to age such as Alzheimer’s. It is also used to aid patients in recovering after a stroke. Some consider Ergoloid mesylate as a nootropic – memory enhancers.
Ergoloid mesylate is marketed under the brand names Gerimal, Hydergine and Hydergine LC. It is also known as dehydrogenated ergot alkaloids.
The usual adult dose of Ergoloid mesylate for the adjunct treatment of dementia syndrome is 1 to 2 mg taken orally three times a day. Ergoloid mesylate capsules are taken orally, and should be dissolved under the tongue.
If Ergoloid mesylate are taken at the recommended dosage, the occurrence of side effects will be from rare to none at all. The incidence of side effects and its severity depend mainly on the dosage taken and the duration that the drug has been introduced to the patient’s body. Most of the reported side effects of ergot alkaloids are usually reversible once therapy has been stopped.
Serious side effects may occur, though the occurrences of such side effects have been significantly low. Such side effects include: bradycardia (slow heartbeat), dizziness caused by orthostatic hypotension, skin rashes. If side effects such as these have been experienced, emergency medical attention must be sought after.
Less serious side effects, which may need medical attention if they persist or become bothersome, include: soreness of the tongue, problems with vision, dizziness, fatigue, headaches, gastrointestinal pains such as cramps, gas pains and diarrhea, and even stuffy nose.
Ergoloid mesylate have been found to be contraindicated in patients with hypersensitivity to ergot alkaloids and their components. It has also been found to be contraindicated in patients with pre-existing medical conditions such as bradycardia, hypotension and severe liver impairment.
Patients undergoing anti-psychotic treatments are prohibited from use of Ergoloid mesylate as some of these drugs, such as dopamine may aggravate the side effects that Ergoloid mesylate may produce.
A patient undergoing ergoloid mesylate therapy must always have their blood pressure levels and their pulse counts closely monitored.
A detailed medical history must be reported to the doctor, including allergies to drugs, heart, liver, blood pressure, liver and even behavioral problems which may exacerbate the effects of the drug and potentially cause harm to the patient.
The use of Ergoloid mesylate on pregnant women must be given caution, and must only be done when clearly needed. The potential benefits of the drug must be weighed accordingly against the risk it poses for the mother and the baby. Although it is not known if Ergoloid mesylate passes onto breast milk, the administration of the drug to nursing mothers must be given caution and consulted with the doctor prior to administration.
Ergoloid mesylate has the following structural formula:
• Molecular formula of ergoloid mesylate is C33H45N5O5
Brand name(s): Alkergot, Circanol, Deapril-ST, Dihydroergotoxine, Gerimal, Hydergin, Hydergine, Ischelium, Redergin, Trigot
Review published on: 28 July 2009
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