Dilacor, known generically as diltiazem, is a heart medication used for treating high blood pressure or hypertension, angina or heart pain, and abnormal heart rhythms or arrhythmia. It belongs to a class of medicines called calcium channel blockers or CCB, which includes nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin), and amlodipine (Norvasc), among many others. CCBs block the entry of calcium into muscle cells that surround the arteries and make up the heart.
It's actually the distribution of calcium into these cells that causes cells to contract, allowing the heart to pump blood and the arteries to narrow. Through blocking the entry of calcium, Dilacor lessens the force of contraction of the heart, reduces its rate of contraction, and—most importantly—decreases the symptoms of high blood pressure. It also acts as a muscle relaxant on the muscles surrounding the arteries, allowing the arteries to dilate, which also helps alleviate the effects of hypertension.
Adult oral doses for Dilacor range between 120 and 480 milligrams administered every day. Immediate release tablets, on one hand, can be taken up to four times daily. Extended release formulations, on the other hand, should only be ingested once daily at approximately the same time each day and should not be chewed or crushed.
The available doses for immediate release Dilacor tablets are 30, 60, 90, and 120 milligrams. The available doses for extended release Dilacor tablets are 120, 180, 240, 360, and 420 milligrams. As for extended release Dilacor capsules, there are 60, 90, 120, 240, 300, 360, and 420 milligram doses available. Finally, for Dilacor liquid solution injections, there are 5 milligrams per milliliter doses available, plus 25 milligrams of Dilacor powder used for injections as well. Consult your doctor or pharmacist on which dose and route is best suited for you.
Administration of Dilacor with drugs like Lanoxin (digoxin) can increase digoxin blood levels. As such, the level of digoxin content in blood is usually monitored to avoid digoxin poisoning. Likewise, simultaneous administration of Dilacor with an anti-seizure drug like Tegretol (carbamazepine) can boost the level of seizure medication in the blood, which can also occasionally lead to toxicity. Use dilacor with due caution when using digoxin- or carbamazepine-based medication.
Don't use Dilacor if you have certain heart ailments such as "AV block" or "sick sinus syndrome" (unless you have a pacemaker), hypotension or low blood pressure, or if you've recently suffered from a heart attack. Also, before undergoing treatment, inform you pharmacist or physician if you allergic to any drugs, or if you have had a history of congestive heart failure, liver disease, or kidney disease.
In addition, keep in mind that Dilacor can cause side effects that can impair your thinking or reactions. You should exercise caution before you drive a vehicle, operate heavy machinery, or do anything that requires you to be awake and alert. You should also not cease taking this medicine without first talking to your physician, because if you stop taking Dilacor abruptly, your condition may relapse and become worse.
Dilacor is best used as a part of a complete program of treatment that involves diet, exercise, and other medications that won't react adversely to this drug. You must follow your diet, medication therapy, and exercise routines very closely to achieve the best possible result. Additionally, if you're being treated for high blood pressure, you must use Dilacor as maintenance, which means you must continue taking this drug even if you feel fine. It's because hypertension often has no symptoms.
Common side effects of Dilacor include dizziness, drowsiness, low blood pressure or hypotension, edema or swelling of the legs with fluid, rash, headache, nausea, and constipation. Overgrowth of the gums and liver dysfunction may also happen. Dilacor can also cause mildly abnormal liver tests that usually return to normal once treatment is over. When Dilacor or any diltiazem-based medication is given to patients who have suffered heart failure, symptoms of the condition may worsen because of the drug's effect on the heart's ability to pump blood. Finally, like many other medications for hypertension, Dilacor is also connected with sexual dysfunction.
Dilacor has the following structural formula:
• Molecular formula of dilacor is C22H26N2O4S
• Chemical IUPAC Name is [2-(2-dimethylaminoethyl)-5-(4-methoxyphenyl)-3-oxo-6-thia-2-azabicyclo[5.4.0] undeca-7,9,11-trien-4-yl]ethanoate
• Molecular weight is 414.519 g/mol
• Dilacor available : 30mg tablets, 60mg tablets, 90mg tablets, 120mg tablets
Generic name: Diltiazem
Brand name(s): Acalix, Adizem, Altiazem, Anginyl, Angizem, Anoheal, Apo-Diltiaz, Britiazim, Bruzem, Calcicard, Cardizem, Citizem, Cormax, Deltazen, Diladel, Dilcontin, Dilpral, Dilrene, Dilt-cd, Diltahexal, Diltia, Diltiazem HCL, Dilticard, Dilzem, Dilzen, Endrydil, Herbesser, Masdil, Novo-Diltazem, Nu-Diltiaz, Syn-Diltiazem, Tiazac Tildiem
Review published on: 16 April 2009
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