Diflorasone is a corticosteroid that is marketed as a topical cream ointment containing the drug diflorasone diacetate. Diflorasone is primarily used for its anti inflammatory and anti-itch qualities, much like most corticosterosis.
Corticosteroids are drugs whose basic action is to reduce the activity of chemicals that make the body swell, itch and inflame. Topical corticosteroids like diflorasone work when they are absorbed by the skin, reacting to the chemicals that make that part of the skin inflamed.
Diflorasone has been widely considered to be a topical drug with a higher potency than other corticosteroids.
Topical diflorasone is used by many to treat skin conditions such as inflammation and itching, which may be caused by allergic reactions, psoriasis or eczema. Diflorasone diacetate is also used to treat lichen sclerosus and a form of T-cell lymphoma called mycosis fungoides.
Diflorasone is a topical ointment that contains 0.5mg of diflorasone diacetate. Diflorasone Diacetate ointment 0.05% is made available in 15, 30 and 60 gram tubes,.
Certain side effects may result from the usage of diflorasone diacetate. The following side effects and reactions may also be experienced with other corticosteroids. Stop using the ointment if sever inflammation, reaction and irritation is experienced using the ointment. Mood changes, weight gain, sleeplessness, and blurred vision may be one of the many major side effects of using diflorasone.
The lesser side effects may include mild reactions to the skin like rashes, dryness, itching, swelling, and thinning. The skin treated with diflorasone may also change color, as hair follicles may also swell up.
There are no known contraindicated drugs with diflorasone, however, topical corticosteroids are known to be contraindicated in patients with a history of hypersensitivity to the components of the ointment.
Once irritation to the skin has formed, discontinue the use of diflorasone and seek emergency medical care. In the case of skin infections, appropriate dermatological agents should be used (anti-fungal or antibacterial cream) alongside the diflorasone diacetate. If the condition is not alleviated, diflorasone use should be stopped until the skin infection is completely healed.
Reports have stated that absorption of topical corticosteroids over time may produce reversible HPA or hypothalamic-pituitary-adrenal axis suppression. It may also produce hyperglycemia and even glucosaria in some patients. This may be caused by application of dosages higher than required or prolonged usage of the drug.
Children are reported to absorb larger amounts of these corticosteroid ointments and are more susceptible to systemic toxicity.
HPA suppression and other complications like Cushing’s syndrome and intracranial hypertension have been reported as cases in pediatric patients receiving topical corticosteroids. Manifestations of these diseases include retarded linear growth, delay in weight gain, low-level plasma cortisols, and the irresponsiveness to ACTH stimulation for adrenal suppression. Intracranial hypertension is manifested in patients with bulging fontanelles, bilateral papilledema and headaches.
Administering topical corticosteroids like diflorasone diacetate to pediatric patients should then be limited to the minimum amount coupled with effective therapy. The chronic use of diflorasone and other corticosteroids may interfere with the growth and development of children.
Diflorasone has the following structural formula:
• Molecular formula of diflorasone is C26H32F2O7
• Chemical IUPAC Name is [17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8, 11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate
• Molecular weight is 494.525 g/mol
Brand name(s): Florone, Maxiflor, Psorcon
Review published on: 15 July 2009
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