Denavir, which is generically prescribed as penciclovir, is commonly used to treat cold sores of the mouth, particularly recurrent cold sores. Denavir is an antiviral cream that works best when it is applied as soon as the earliest symptoms appear.
Denavir is not appropriate for everyone. A thorough medical history should be assessed prior to prescribing this medication. Patients with a medical history which includes skin sensitivities, skin conditions, or skin allergies may not be able to use Denavir or may require careful monitoring while undergoing drug therapy with this medication, depending on the condition and the severity of the condition.
The American Food and Drug Administration rated this medication as a pregnancy risk category B. Denavir is not expected to cause harm or birth defects to an unborn baby. This medication has not yet been determined to either pass or not pass into the mother’s breast milk or whether or not it affects a nursing baby. The prescribing physician should discuss whether or not the benefits outweigh the risks of prescribing Denavir to a pregnant woman. The prescribing physician should avoid prescribing this medication to a woman who is nursing.
There is a risk of side effects associated with Denavir, some of which are severe. If a patient is experiencing a serious side effect or an allergic reaction, they should seek immediate emergency medical attention. An allergic reaction will present with symptoms which include facial swelling, such as selling of the lips, mouth, tongue, or throat, hives, and difficulty breathing. Other serious side effects which require emergency medical attention include severe skin reactions that may present with swelling, blistering, or an intense burning sensation.
Other less serious side effects typically do not require emergency medical attention but should be reported to the prescribing physician. Patients should be encouraged to report all side effects. Less serious side effects include symptoms such as changes in taste, headache, rash at the application site, numbness at the application site, tingling at the application site, or any type of skin irritation at the application site. If any other side effect occurs, especially one that is considered to be especially bothersome, it should be reported to the prescribing physician immediately. Less serious side effects can often be reduced to a tolerable level by reducing the dosage of Denavir.
Denavir should be applied exactly as it has been prescribed by the physician. If the patient misses a dose, the dose should be applied as soon as it is remembered. However, if it is almost time for the next scheduled application, the missed dose should be skipped to avoid the potential for an overdose. The patient should never apply a double dose of this medication. If an overdose is suspected, the patient should seek immediate emergency medical attention. While an overdose is not likely to cause severe symptoms, it may present with swelling of the affected area, burning or a numb and tingly feeling, and in some cases a serious rash.
Denavir should be kept out of reach of children. If ingestion occurs, the patient should be taken to the nearest emergency treatment facility immediately. Ingestion may cause stomach problems, including but not limited to nausea, diarrhea, vomiting, and burning of the esophagus.
There is a risk of drug interactions associated with Denavir. A thorough medical history should be understood prior to prescribing this medication. Patients should be urged to inquire with the prescribing physician before taking any new medications, including over the counter medications and herbal remedies. Medications with known negative interactions with Denavir include topical creams for other skin problems, including acne medication.
Denavir has the following structural formula:
• Molecular formula of denavir is C10H15N5O3
• Chemical IUPAC Name is 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3,9-dihydropurin-6-one
• Molecular weight is 253.258 g/mol
• Denavir available : 1% cream 1.5gm tube
Generic name: Penciclovir
Brand name(s): Penciclovirum
Review published on: 06 April 2007
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