An effective medication for fighting depression is Damitriptyline, a tricyclic antidepressant. It works by inhibiting the serotonin and the noradrenaline reuptake in a patients body and actually increases the level of those natural chemicals so that the level of depression decreases. Typically sold under the names Elavil, Tryptanol, Endep, Elatrol, Tryptizol, Trepiline, and Laroxyl. This medication also has sedative effects, so it can also be used to calm people with anxiety or violent depression.
This medication is most often used by healthcare professionals to treat clinical depression and depression in the elderly; however, in some countries it is used to treat chronic migraines, chronic pain, carpal tunnel syndrome and insomnia. In 2003, a study compared Damitriptyline with a control group of anti depressants, and almost 90% of the subjects had a more favorable response with Damitriptyline.
Common side effects of this medication include dry mouth, drowsiness, dizziness, blurred vision, insomnia and weight gain. Due to the drowsiness and dizziness patients experience while taking this medication, they should not drive or operate heavy machinery while taking Damitriptyline. Less common side effects include mania, hypotension, psychosis, and hepatic toxicity. If you experience any of these symptoms contact your healthcare professional immediately.
Patients with a history of seizures, liver diseases, blood diseases, hyperthyroidism, constipation and glaucoma need to advise their healthcare professional of these conditions before taking Damitriptyline since these conditions may hinder the effects of the medication. Patients with heart disease need to be particularly careful as this medication can cause abnormal rhythms in the heart. Patients with bipolar disorder may experience hypermaniac attacks if given Damitriptyline, therefore healthcare professionals may want to adjust the dose or prescribe a different medication for those patients. The use of Damitriptyline has not been approved for pregnant or breastfeeding women. It is known that the medicine is passed through breast milk so mothers should not nurse their children while they are taking the medication.
Patients should talk with their healthcare professional about any and all medication that they are taking before they use Damitriptyline. Medications like cisapride, monoamine oxidase inhibitors, Marplan, Nardil, Eldepryl, Emsam, Zelapar and Parnate have negative interactions with Damitriptyline. Any medication you are taking may react negatively with Damitriptyline, even simple medications like sleeping pills, antihistamines, diet pills, or herbal vitamins. Make certain that your healthcare professional is aware of every medication you are taking, even those that are non-prescription, to be safe.
Damitriptyline should only be taken as prescribed. The tablets are small, white and odorless and come in 10, 25, 50 and 70 mg tablets. The dosage for adults and the elderly is usually 25 to 150 mg daily depending on the severity of the condition being treated. It is very important to take the prescribed dosage as too much of the medication may have negative affects on your mental health.
Damitriptyline has the following structural formula:
• Molecular formula of damitriptyline is C20H23N
• Chemical IUPAC Name is 3-(10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
• Molecular weight is 277.403 g/mol
• Damitriptyline available : 10mg tablets, 25mg tablets, 50mg tablets, 75mg tablets, 100mg tablets, 150mg tablets
Generic name: Amitriptyline
Brand name(s): Adepress, Adepril, Amineurin, Amitid, Amitril, Amitriprolidine, Amitriptylin, Amitryptiline, Amitryptyline, Amytriptiline, Damilan, Damilen, Elanil, Elavil, Endep, Flavyl, Hexathane, Horizon, Lantron, Laroxil, Laroxyl, Lentizol, Pamelor, Proheptadiene, Redomex, Saroten, Sarotex, Seroten, Sylvemid, Triptanol, Triptilin, Triptisol, Tryptanol, Tryptizol
Review published on: 15 January 2010
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