An effective and well known medication that fights depression is Damilen, a tricyclic antidepressant. It works by inhibiting the serotonin and the noradrenaline reuptake in a patients body and actually increases the level of those natural chemicals so that the level of depression decreases. Typically sold under the names Elavil, Tryptanol, Endep, Elatrol, Tryptizol, Trepiline, and Laroxyl, it has sedative effects, so it can also be used to calm people with anxiety or violent depression.
This medication is most often used by physicians to treat clinical depression and depression in the elderly; however, in some countries it is used to treat chronic migraines, chronic pain, median neuropathy at the wrist and insomnia. A study done in 2003 compared Damilen with a control group of anti depressants, and almost 90% of the subjects had a more favorable response with Damilen.
Common side effects of this medication include xerostomia, drowsiness, dizziness, blurred vision, insomnia and weight gain. Due to the drowsiness and dizziness patients experience while taking this medication, they should not drive or operate heavy machinery while taking Damilen. Less common side effects include mania, abnormally low blood pressure, psychosis, and hepatic toxicity. If you experience any of these symptoms contact your physician immediately.
Patients with a history of seizures, liver diseases, blood diseases, hyperthyroidism, constipation and glaucoma need to advise their physician of these conditions before taking Damilen since these conditions may hinder the effects of the medication. Patients with heart disease need to be particularly careful as this medication can cause abnormal rhythms in the heart. Patients with bipolar affective disorder may experience hypermaniac attacks if given Damilen, therefore physicians may want to adjust the dose or prescribe a different medication for those patients. The use of Damilen has not been approved for pregnant or breastfeeding women. It is known that the medicine is passed through breast milk so mothers should not nurse their children while they are taking the medication.
Patients should talk with their physician about any and all medication that they are taking before they use Damilen. Medications like cisapride, monoamine oxidase inhibitors, Marplan, Nardil, Eldepryl, Emsam, Zelapar and Parnate have negative interactions with Damilen. Any medication you are taking may react negatively with Damilen, even simple medications like sleeping pills, antihistamines, diet pills, or herbal vitamins. Make certain that your physician is aware of every medication you are taking, even those that are non-prescription, to be safe.
Damilen should only be taken as prescribed. The tablets are small, white and odorless and come in 10, 25, 50 and 70 mg tablets. The dosage for adults and the elderly is usually 25 to 150 mg daily depending on the severity of the condition being treated. It is very important to take the prescribed dosage as too much of the medication may have negative affects on your mental health.
Damilen has the following structural formula:
• Molecular formula of damilen is C20H23N
• Chemical IUPAC Name is 3-(10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
• Molecular weight is 277.403 g/mol
• Damilen available : 10mg tablets, 25mg tablets, 50mg tablets, 75mg tablets, 100mg tablets, 150mg tablets
Generic name: Amitriptyline
Brand name(s): Adepress, Adepril, Amineurin, Amitid, Amitril, Amitriprolidine, Amitriptylin, Amitryptiline, Amitryptyline, Amytriptiline, Damilan, Damitriptyline, Elanil, Elavil, Endep, Flavyl, Hexathane, Horizon, Lantron, Laroxil, Laroxyl, Lentizol, Pamelor, Proheptadiene, Redomex, Saroten, Sarotex, Seroten, Sylvemid, Triptanol, Triptilin, Triptisol, Tryptanol, Tryptizol
Review published on: 14 January 2010
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