Clomifene is a drug used for the treatment of infertility among women. It stimulates increased amount of hormones vital to the growth and the release of mature egg for ovulation.
Clomifene is available in tablet form. It is marketed under the brand names Clomin, Milophene, Serophene, Clomid, Androxal, Clomifert, Clomiphene, Clomivid, Clomphid, Clostilbegyt, Dyneric, Omifin, and Ikaclomin.
Women who are having difficulties getting pregnant may take Clomifene. It may also be used in tandem with a medicine called Metformin to help users ovulate and become pregnant.
Studies reveal that 70 % of those who used Clomifene were able to ovulate, a good majority of them during the first months of the treatment. Of that rate, about 15-50% were able to become pregnant.
Women are prescribed to take 50 milligrams of Clomifene for 5 days beginning on the fifth day of their menstrual cycle. In case an ovulation does not happen, dosage can be increased to 100 milligrams for 5 days a month after the previous dosage. It is not advised however the women take Clomifene after 6 treatment cycles.
Following the dosing schedule is important for users to get the best results. Users should not take the tablet for a longer period than what the doctor prescribed. In case of a missed dose, users should immediately inform their doctors for instructions. It is not recommended that users take double doses to catch up on their dosing schedule.
For best results, physicians may look into several records like the body temperature of the user. Users may also take ovulation tests prior to taking Clomifene.
Users of Clomifene may experience side effects such as upset stomach, hot flashes, pelvic fullness, headache, breast tenderness, or dizziness. In case any of these symptoms persist, users should immediately notify their physicians. Most of the time, however, the chances of a user getting these side effects are low.
Users may also experience changes in their vision such as seeing flashes while taking Clomifene. This is especially true if they are exposed to intense lighting. This may go away after a couple of days after treatment.
Other serious side effects may also occur like vaginal bleeding and changes in moods. Some users may also experience severe pain or swelling in the pelvic area, diarrhea, difficulty in breathing, chest pain, irregular heartbeat, nausea, and swelling of the legs.
Before agreeing to take Clomifene, women should inform their doctor about any history of allergy to drugs. Women should also consult their physician about their conditions such as liver disease, vaginal bleeding, uncontrolled thyroid, and pituitary tumor before agreeing to use Clomifene.
There have been cases in the past wherein the use of Clomifene resulted to the user having multiple births like twins and triplets.
Women are also advised against engaging in activities that require mental alertness such as driving since Clomifene can make a person dizzy or suffer from blurred vision.
Users should inform their physicians or pharmacist bout all the prescription medicines they are using before taking Clomifene.
Clomifene has the following structural formula:
• Molecular formula of clomifene is C26H28ClNO
• Chemical IUPAC Name is 2-[4-[(Z)-2-chloro-1,2-di(phenyl)ethenyl]phenoxy]-N,N-diethylethanamine
• Molecular weight is 405.9596 g/mol
• Clomifene available : 50mg tablets
Brand name(s): Androxal, Clomid, Clomifen, Clomifert, Clomiphene, Clomiphene B, Clomivid, Clomphid, Clostilbegyt, Dyneric, Genozym, Ikaclomin, Milophene, Omifin, Serophene
Review published on: 03 July 2009
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