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Cefepime review by Medicalook.com
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Cefepime is an antimicrobial drug. It is classified under fourth generation cephalosporin antibiotics, which is often used to treat moderate to severe pneumonia and other bacterial infections. Lately, Cefepime is rarely used due to an FDA early communication regarding its safety. The article, Efficacy and Safety of Cefepime: A Systematic Review and Meta-analysis, was published in May 2007 at The Lancet Infectious Diseases. It is basically about an ongoing review of Cefepime’s effectiveness against an increased mortality rate connected to its use.
Cefepime was developed in early 1990s. It was marketed in 1994 under numerous trade names and has been found effective in treating both Gram-positive and Gram-negative organisms. Aside from pneumonia and other respiratory tract infections, Cefepime is also used to treat complicated episodes of urinary tract infections, skin infections, and intra-abdominal infections. It is also often used as an Empiric Therapy for Febrile Neutropenic Patients. The effectiveness of Cefepime over other antibacterial drugs lies in its great activity against susceptible bacteria.
Cefepime is a liquid suspension administered intravenously. It is either injected to your large muscle in the hip or in the buttock or added to an intravenous fluid dripping through your veins every 12 to 24 hours. Doctor’s supervision is significant in Cefepime use because the doctor is the only one who could tell you whether it is applicable to treat your current illness or not. A patient using Cefepime treatment is also closely watched to ensure that the effectiveness of the drug is greater than its side effects. Physical examinations and laboratory testing are ordered to monitor how the patient’s symptoms respond to the treatment.
The dosage required for an adult per day and for how long depends on the severity of his affliction as well as his medical history. Dosage adjustments are necessary for people with certain conditions. As such, you must openly talk your doctor through your medical records. People who have allergies; who are currently taking other medicines; who have had bouts with kidney, liver, and gastrointestinal diseases; who are pregnant or are planning to become one; and who have diabetes are especially looked through. It is highly important for a patient’s safety to follow the prescription closely. Do not try to alter it without the knowledge of your healthcare provider. Ceasing to take Cefepime due to an early improvement of your symptoms might just give the bacteria a breathing space to thrive and cause more damage.
Cefepime use may come with diarrhea, stomach pain, and vomiting as side effects. If those symptoms persist or worsen as you continue with the treatment, head for your doctor immediately. Skin rash, breathing difficulty, unusual bleeding or easy bruising, hives, and sore throat are not common for patients under Cefepime therapy. If such symptoms occur at any point of your treatment, call your doctor.
At the light of doubts looked upon by FDA itself regarding Cefepime’s safety, it would be best to ask for an alternative medication you could use for your condition. If your doctor insists on Cefepime use, make sure that you are monitored closely to be on the safe side.
Cefepime has the following structural formula:
• Molecular formula of cefepime is C19H24N6O5S2
• Chemical IUPAC Name is (6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2- methoxyiminoacetyl]amino]-3- [(1-methylpyrrolidin-1-ium-1-yl)methyl]-8- oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• Molecular weight is 480.5611 g/mol
• Cefepime available : 100mg tablets
Brand name(s): Axepim, Cefepima, Cefepimum, Cepimax, Cepimex, Maxcef, Maxipime
Review published on: 11 April 2008
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