Caverject, also known as Prostaglandin E1, is used to manage erectile dysfunction through its vasodilatory features. It is sold in the United States under the brand name Muse or Medicated Urethral Suppository for Erection by Vivus. It is also available as Caverject, one of the brand names for its injectable form. Muse transports the medication as a penile drug delivery system inserted into the urethra for at least ten minutes before you want an erection. In contrast, the likewise fast-acting Caverject is injected directly into the penis's corpus cavernosum.
This medication is recommended for men with erectile dysfunction. You can also use this medication to preserve a patent ductus arteriosus in a newborn. This is mostly effective when there is a danger of premature ductus arteriosus closure in a baby with ductal-dependent congenital heart disease including acyanotic lesions (that is, interrupted aortic arch, critical aortic stenosis, hypoplastic left heart syndrome, and coarctation of the aorta).
This medication is taken as needed to achieve penile erection. The effects are noticeable about five to ten minutes after administration and can last from about thirty minutes to an hour. Dosage is determined by your doctor and you will be examined for any negative side effects afterwards. Follow the approved instructions precisely. You should be instructed in detail on how to administer the medication by your doctor before trying to do so by yourself. Each product is for single use only and should not be used repeatedly.
Common side effects of Caverject include headache, flu symptoms, palpitations, dizziness, minor penile bleeding or spotting, and penile/testicular pain. If any of these adverse effects persist or worsen, consult your doctor immediately. You should also report the very rare but grave side effects of severe unsteadiness or fainting due to possible blood pressure decrease.
As for the side effects for your female partner, she may sometimes experience vaginal burning or itching after sex. It is currently unclear if this has anything to do with the medication itself or not. If you notice any other side effects not listed in this article, immediately contact your doctor to discuss them.
Before taking this medication, talk with your doctor about of all the prescription and nonprescription medications you have been taking, especially medicines that can sometimes cause erection problems like MAO inhibitors (furazolidone, selegiline, phenelzine), blood thinners (aspirin, warfarin, NSAIDs), phenothiazines (chlorpromazine), anti-anxiety medications, calcium channel blockers or other high blood pressure medications, hydralazine, terazosin, prazosin, propranolol (beta-blockers), guanfacine, guanabenz, disopyramide, clonidine, thiazide water pills, methyldopa, spironolactone, and tricyclic antidepressants. Do not start or stop taking any medicine without prior doctor recommendation.
Inform your doctor of your medical history before taking this medication, especially if you have a history of allergies, prolonged erections from other medications, cancer, physical penis abnormalities, blood or bleeding disorders, low blood pressure, or heart disease. You should also be aware that this medication offers zero protection against sexually transmitted infections such as Hepatitis B or HIV (AIDS).
Overdosing with Caverject can lead to having a painful and persistent erection for hours on end. If left untreated, this can cause you to have a permanent inability to have an erection. Seek emergency medical attention if you experience a prolonged and agonizing erection after using this medication.
Caverject has the following structural formula:
• Molecular formula of caverject is C20H34O5
• Chemical IUPAC Name is 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)-5-oxo-cyclopentyl]heptanoic acid
• Molecular weight is 354.481 g/mol
• Caverject available : 500mg tablets
Generic name: Alprostadil
Brand name(s): Befar, Edex, Muse, Prink, Prostaglandin E1, Prostin VR
Review published on: 16 December 2009
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