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Budesonide review
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Budesonide is a drug commonly used to treat bronchial asthma, or those who are suffering from a range of respiratory problems related to nasal problems. It is a glucocorticoid steroid that interacts with hydrocortisone or cortisol, the two that are naturally produced by the body via the adrenal glands. Its main payload upon inhalation is to have an anti-inflammatory process or effect, which in turn lessens the possible reaction of the airways prior to asthma attacks. This in turn causes a retardation of the initial hypersensitivity of the main airways. Spasms are prevented, and ultimately allow better air to pass through for proper respiration.
It should be stressed out that Budesonide should not be given during an actual asthma attack but only as a preventive measure of coming up with an asthma attack.
Budesonide is administered on patients who may have problems with hypersensitivity attacks that entail constricting of airways. It may also be prescribed on patients who have allergic reactions that also lead to the same constriction pattern. The medication of budesonide is given to treat long-term ailments for asthma and the like. This is also recommended to be prescribed to patients who have difficulty breathing at night, or those with paroxysmal nocturnal asthma attacks.
Since the drug should not be administered to acute attacks of asthma. Usually, prescription for this drug is given to patients who are more than six years of age. The immediate effects of the drug may be seen as early as 24 hours after initial administration, while full effect of the drug would be significantly seen within 1 to 2 weeks.
For adults, they may be prescribed with 1 to 4 puffs, two times a day. As for children, the rate is usually halved, with 1 to 2 puffs, and also twice per day. There are some instances wherein some physicians use this to treat mild asthma. In this aspect, the number of puffs would still be based on the age of the patient, but the frequency per day is halved.
Usual side effects of ingesting this medication are either mild cough or wheezing. A bronchodilator such as Ventolin, or any albuterol generic drug usually counters this. This counter medication is taken prior to taking budesonide, to prevent occurrence of the side effect.
There are some instances wherein oral thrush may thrive. Usual statistics are about 1 in every 25 patients, but is considered to be caused by either a weakened immune system, or improper hygiene especially with the patients’ care and cleanliness in between puffs.
A long-term side effect of the glucocorticoid content of budesonide may alter and decrease the calcium and bone formation of patients, which may cause osteoporosis.
Its interaction with other drugs is very minimal, except for those using Ketoconazole in their medication. It is documented that the presence of Ketoconazole in the body increases the amount of retained budesonide in the blood as well. This may account in the increased chance of a side effect. General precautions should be given to those who are pregnant.
Budesonide has the following structural formula:
• Molecular formula of budesonide is C25H34O6
• Budesonide available : nasal spray 32 mcg
Brand name(s): Bidien, Budeson, Cortivent, Desonide, Desowen, Entocort, Micronyl, Preferid, Pulmicort, Rhinocort, Rhinocort Aqua, Spirocort, Tridesilon
Review published on: 19 June 2009
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