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Bortezomib review
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Bortezomib is the first proteasome inhibitor tested on humans for therapeutic purposes available with the brand name Velcade. It is currently an approved treatment in the United States for cases of mantle cell lymphoma and relapsed multiple myeloma and is available in IV injections. Bortezmoib works by inihibiting the function of certain protein-producing enzymes found inside cancer cells. This limits their growth and may stop the spread of the tumor.
Bortezomib is often given to people who have multiple myeloma and mantle cell lymphoma when at least one other medication or treatment used previously seems to have absolutely no effect at all.
Bortezomib comes in an injection solution that is administered through a vein. It may administered via a central line inserted into a vein beneath the skin near the collarbone, or via a PICC line inserted into a vein near the bend of the arm. The schedule of doses usually alternates 2 weeks when bortezomib is administered 2 times a week which is followed by 10 days when the medication is not given. Each dose will be given a 72-hour buffer period during this critical period where the medication is being administered. The schedule may go on for around eight cycles. If the doctor decides to continue your treatment, he may have to administer smaller doses of the drug.
Before applying bortezomib into the IV, check the solution for any visible particles or any discoloration. If either is found in the medication, do not attempt to administer the solution.
Bortezomib may bring about certain side effects while on treatment. Among the minor ones include weakness and anxiety, nausea and vomiting, stomach pain, diarrhea, body pains and difficulty either in sleeping or in staying awake. Consult with your doctor if these symptoms persist.
However, some side effects may need immediate medical attention. These include severe allergy symptoms such as persistent fevers, rashes and swelling, unusual color or presence of blood in stool, mental confusion and loss of coordination, irregular heartbeats and fainting and painful or burning sensations in the hands, among others.
Inform your doctor if you are going to be undergoing surgery while on this medication, to prepare for any conflicting medication. Also, inform him of your medical history with emphasis on any cases of heart disease, high cholesterol, herpes infection, blood pressure conditions or any liver o kidney disease. These conditions may hinder you from taking bortezomib. List down all current medication you are taking and give a copy to your doctor so that any conflicting medication can be anticipated and be dealt with.
Bortezomib will also cause drowsiness, so be careful when performing dangerous or complicated tasks. Drink plenty of water to remain hydrated and avoid alcohol while on bortezomib treatment. Ask your doctor if consuming grapefruit would be safe while on medication.
Get up to your feet or from bed slowly while on bortezomib treatment, as you are more prone to fainting due to dehydration or blood pressure drugs.
Bortezomib has the following structural formula:
• Molecular formula of bortezomib is C19H25BN4O4
• Chemical IUPAC Name is [3-methyl-1-(3-phenyl-2-pyrazin-2-ylcarbonylamino-propanoyl)amino-butyl]boronic acid
• Molecular weight is 384.237 g/mol
Brand name(s): Velcade
Review published on: 17 June 2009
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