Bextra, also known as valdecoxib, is a nonsteroidal anti-inflammatory drug or NSAID utilized to alleviate swelling, inflammation, and pain. It is mostly used to treat maladies such as arthritis, including osteoarthritis or rheumatoid arthritis. Because it is an NSAID, it should not be taken by anyone who is allergic to this type of medication.
Bextra was approved by the FDA on November 20, 2001, and is distributed commercially by prescription in tablet form up until 2005, which was the year it was recalled and removed from stores due to fears about increased chances of having a stroke or heart attack while under Bextra treatment.
The recommended daily dosage of Bextra for either osteoarthritis or rheumatoid arthritis is 10 milligrams one every day. On the other hand, the advised dose for treatment of primary dysmenorrhea is twice that—that is, it's 20 milligrams twice daily as required. Dosage may change in accordance to the doctor's prerogative and prescription. Bextra may be taken with or without food.
Inform your doctor or pharmacist if you're allergic to Bextra or to sulfa drugs before undergoing treatment; NSAIDs like ibuprofen, celecoxib, ibuprofen, and other valdecoxib brands' or have any other allergies on the whole. It is also not recommended for you to take this valdecoxib brand if you suffer from medical conditions such as kidney disease or severe liver disease.
On that note, you must report to your doctor about your medical history as well, especially if you have had or are currently having bouts of heart disease, liver problems, stomach problems involving internal bleeding and ulcers, asthma, blood disorders like anemia, swelling problems due to fluid retention, nasal polyps, dehydration, persistent runny nose, high blood pressure, and other conditions caused by continuous tobacco or alcohol use.
Drugs related to valdecoxib infrequently have caused blood cots to form, which usually results to heart attacks and strokes. Moreover, this medication rarely causes similar complications in heart bypass patients after surgery, but not in other people examined to date. Therefore, you must consult with your doctor or pharmacist about the advantages and disadvantages of Bextra treatment in order to determine if you should continue treatment or just try out other possible drug alternatives.
Life-threatening allergic reactions have been reported with Bextra and other valdecoxib-based drugs, so it is advised for patients who experience rash and any other allergy symptoms to halt using Bextra and seek medical advice from their physician as soon as possible. Even though Bextra, in contrast to celecoxib-based drugs, is not a sulfonamide, it is still discouraged for people with allergic reactions to sulfonamides to take this particular medicine.
Bextra should only be taken when clearly needed during pregnancy, but it should not be used at all if the pregnancy has already reached its third trimester. More to the point, it is currently not known whether or not Bextra passes into breast milk, so you must exercise due caution if you're a breastfeeding mother. Simply put, it is not recommended for mothers to breastfeed their children while under Bextra treatment.
The most common side effects for Bextra include stomach bleeding, flatulence, abdominal pain, insomnia, diarrhea, nausea, and headache. Other rarer side effects include weakness of the body, fainting, flu-like symptoms, stomach and intestinal ulcers, bleeding, blurred vision, anxiety, fluid retention, deafness, drowsiness, ringing in the ears, weight gain, worsening of pre-existing hypertension, chest pain, kidney failure, and photosensitivity.
Bextra has the following structural formula:
• Molecular formula of bextra is C16H14N2O3S
• Chemical IUPAC Name is 4-(5-methyl-3-phenyl-oxazol-4-yl)benzenesulfonamide
• Molecular weight is 314.36 g/mol
• Bextra available : 10mg tablets and 20mg tablets
Generic name: Valdecoxib
Review published on: 13 April 2009
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