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Balsalazide review
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Balsalazide is an anti-inflammatory drug used in treating inflammatory bowel diseases like active ulcerative colitis. Balsalazide releases mesalamine once it reaches the large intestines (which are believed to be the active sites for ulcerative colitis) and reduces swelling within the lining of the intestines in order to allow it to heal. It can then help further reduce recurrence of the symptoms. It is a prescription drug marketed as Colazal in the United States and Colazide in the United Kingdom – both brands come in 750 mg capsules.
Balsalazide is used to treat ulcerative colitis as it alleviate symptoms like diarrhea, stomach pain and rectal bleeding. It may be helpful in treating Crohn's colitis and lymphocytic or microscopic colitis as well. It is prescribed to patients 5 years and older.
The usual adult dose is to take 3 capsules a day at evenly spaced intervals. This treatment usually will last about 8 weeks or until condition improves. A child’s dose may consist of only a single capsule per day. The treatment may last as long as 12 weeks but know studies have been conducted to verify benefits of further extending the treatment.
An alternative way to take balsalazide is to open a capsule and sprinkle the contents onto a tablespoon of applesauce before swallowing the mixture immediately. The contents may need to be chewed especially if the contents of the capsules are in larger fragments. Color variation may occur and teeth staining may be experienced when balsalazide is consumed like this.
Take skipped dose as soon as possible and resume treatment as scheduled. Do not take twice the dose to compensate for a missed dose.
Some commonly experienced side effects from taking balsalazide include headaches, insomnia, nausea and vomiting, stomachache, diarrhea, cold-like symptoms and joint pain. If any of these becomes particularly bothersome then consult your doctor.
More serious effects include aggravated colitis symptoms such as rectal bleeding, stomach cramps and bloody stools. Some may even experience paleness and easy bruising. Jaundice, passing dark urine and bloating may also arise rarely. If any of these symptoms occur, immediately discontinue the use of balsalazide and consult your doctor.
Consult your doctor before taking this medication and inform him if you are pregnant or breastfeeding. It may not be recommended to take this medication while pregnant.
Kidney and liver problems may pose complications while taking balsalazide, so inform your doctor about these conditions as well. Other conditions that should be reported to your physician include asthma, stomach ulcers or duodenal ulcers (as opposed to those in the colon), and blood conditions. Inform him of any medication you are currently taking, including methorexate and digoxin. Doctors will also want to know if you have experienced allergic reactions from balsalazide or other salicylates such as aspirin or mesalazine. Hypersensitivity or allergic reactions may include anaphylaxis, tightening of the airways and skin reaction such as rashes, but other symptoms may also manifest and is not limited to those mentioned.
Balsalazide has the following structural formula:
• Molecular formula of balsalazide is C17H15N3O6
• Chemical IUPAC Name is 5-[4-(2-carboxyethylcarbamoyl)phenyl]diazenyl-2-hydroxy-benzoic acid
• Molecular weight is 357.318 g/mol
• Balsalazide available : 750mg tablets
Brand name(s): Balsalazida, Balsalazido, Balsalazidum, Carbadox, Colazal
Review published on: 12 June 2009
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