An antibacterial agent originally manufactured by GlaxoSmithKline, Bactroban is the brand name of mupirocin, which is derived from the fermentation of Pseudomonas fluorescens and is effective against gram-positive bacteria including Streptococcus pyogenes, Staphylococcus aureus (MRSA), and several gram-negative bacteria. In any case, mupirocin ointment is marketed as Bactroban Calcium Cream 2%—which includes the dihydrate crystalline calcium hemi-salt—and the Bactroban Nasal Ointment 2%.
Like many other topical antibiotics like it, Bactroban essentially works by hampering the creation of bacterial protein by fastening to the bacterial isoleucyl transfer-RNA synthetase. It has also been found to have no risk of cross-resistance with other antimicrobial agents, unlike many other medications. However, prolonged use increases one's chances of developing resistance to the antibiotic's effects as well as secondary infections from non-bacterial agents like fungi.
A small amount of the Bactroban cream—about a pea-sized amount—should be applied to the affected area when treating conditions like impetigo, usually done about five times daily. The area may be covered with sterile gauze dressing to obtain optimum antibiotic benefits. If you experience no improvement in three to five days, your doctor or dermatologist should be consulted with in order to re-examine the infected area.
For other skin infections in general, the cream should be administered to the affected area three times a day for ten days. Your doctor dermatologist should also be contacted if there is no improvement within three to five days.
For patients of about twelve years and older who suffer intranasal Staphylococcus aureas that are resistant to many other antibiotics, a Bactroban nasal ointment application of about half of the ointment from a single-use tube should be administered to one nostril, and the other half into the other nostril. This dose should be repeated two times a day for five days.
Bactroban cream should be used according to the doctor's prescription. It should also be used for the full course of treatment for optimum benefit and to avoid relapse or the development of mupirocin-resistant bacteria. On the other hand, it should not be used for longer than instructed.
If your condition appears to worsen instead of improve after three days of therapy, inform your doctor, dermatologist, or pharmacist at once. There are presently no recognized drug and food interactions with Bactroban. The cream version of the Bactroban brand should be applied topically to open wounds and impetigo, a skin infection, but it is not advised for use on mucosal surfaces like the eyes.
The Food and Drug Administration or the FDA has classified the Bactroban antibacterial agent as Pregnancy Category B, which means that there appears to be no detrimental effects on its use by pregnant women. However, it is advised that Bactroban should only be used if you have no other alternative for treatment. The same advice applies to nursing mothers as well.
Bactroban cream has been approved for administration on children from three months to sixteen years. On the other hand, the Bactroban nasal ointment is mostly approved for patients twelve years and up. At present, there is not enough information in regards to recommended daily dosage of Bactroban nasal ointment in children younger than twelve years of age. Whichever the Bactroban brand, in case of an allergic reaction, you must halt treatment immediately.
Common side effects connected with Bactroban cream usage may include secondary wound infection and dizziness, pruritus or itching, dermatitis, cellulites, ulcerative stomatitis, burning sensation, abdominal pain, nausea, rashes, and headaches. As for Bactroban nasal ointment treatment, the most common side effects are taste perversion, pharyngitis, and rhinitis. There are also incidences of headache, respiratory disorders, respiratory tract congestion, burning or stinging of the nasal passages, coughing, and pruritus or itching reported.
Bactroban has the following structural formula:
• Molecular formula of bactroban is C26H44O8
• Chemical IUPAC Name is 13-[3,4-dihydroxy-5-[[3-(3-hydroxybutan-2-yl)oxiran-2-yl]methyl]oxan-2-yl]- 12-methyl-10-oxo-tridec-11-enoic acid
• Molecular weight is 484.623 g/mol
Generic name: Mupirocin
Brand name(s): Bactoderm, Centany, Mupirocine, Turixin
Review published on: 12 April 2009
 Your Bactroban review
| .: Add date: 2009-10-17 15:02:22 |
.: Score: 1 |
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this bactroban has made me loose complete sensation of taste im going on two weeks from the time i quit and have only gotten worse and can hardley drink or eat cause everything taste of metal
Added by coy hamilton
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