Bayer AG has developed Moxifloxacin—initially called BAY 12-8039, also known by the brand name Avelox or Avalox in some countries—a synthetic flouroquinolone antibiotic agent that is marketed worldwide as a hydrochloride used for oral treatment. Its counterpart, Vigamox, is basically Moxifloxacin in ophthalmic solution or eye drops form used for the treatment of conjunctivitis.
Each tablet typically contains 400 milligrams, and in other countries, the medication is also available in parenteral form for intravenous infusion. Among the kinds of bacteria most susceptible to this antibiotic are most forms of Staphylococcus infection, Moraxella catarrhalis, Bacillus anthracis, and many more.
Whether it's in oral form or intravenous infusion form, the designated amount of one Avelox dose is the aforementioned 400 milligrams. It should be taken once every day, and the duration of therapy depends on the type of infection a patient has.
To give you a better idea, the treatment of Acute Bacterial Sinusitis usually lasts for ten days, Acute Bacterial Exacerbation of Chronic Bronchitis for five days, Community Acquired Pneumonia for seven to fourteen days or one to two weeks, simple skin infections for one week, complicated skin infections for one to three weeks, and complicated intra-abdominal infections for five to fourteen days.
Avelox oral tablets should, as its name suggests, be taken by mouth, with or without food, and usually one a day or as directed by your healthcare specialist. Drink plenty of water or fluids while using this drug unless your doctor advices otherwise. Don't take more doses than prescribed.
The patient should undergo susceptibility and culture examinations before Avelox treatment in order to identify and isolate the organisms causing the infection in the first place. The test will also reveal how susceptible the bacteria are to the antibiotic. Therapy with moxifloxacin may be started before the results of the analysis are acquired. After the outcome becomes clear, suitable therapy should be applied accordingly.
Avelox should only be used to treat or prevent infections proven to be caused by bacteria typically susceptible to the medicine. Otherwise, the risk of developing drug-resistant bacteria and decreasing the effectiveness of this drug and other antibacterial drugs will become high. If susceptibility and culture information is accessible, they should be taken into consideration when modifying or even selecting a given antibacterial therapy. If the doctor has not such data, then local and established susceptibility or epidemiology patterns may be used to help the empiric selection of proper therapy.
Moreover, this drug should be taken eight hours after or four hours before taking any medication that contain aluminium, bismuth, subsalicylate, iron, zinc, or magnesium; that is, medicines like certain forms of didanosine—regardless if they're chewable or dispersible buffered tablets or pediatric oral solutions—antacids, vitamins, minerals, guinapril, and sucralfate.
Side effects may include diarrhea, nausea, or dizziness. If any such effects continue or become aggravated, call your pharmacist or doctor immediately. Also tell him or her as soon as possible if any of the following unlikely but serious side effects occur: mental or mood changes, rare thoughts of suicide, tingling or numbness of the hands or feet, swelling of the arms or legs, and uncontrolled movements or tremor.
Furthermore, contact your doctor immediately if any of these extremely rare but grave side effects happen: fainting, fast or irregular heartbeat, chest pain, fever, persistent sore throat, any other new symptom of infection, easy bruising or bleeding, sever stomach or abdominal pain, persistent nausea or vomiting, dark urine, yellowing of the skin or eyes, and seizures.
Keep in mind that Avelox is known to infrequently cause tendon damage—for instance, tendon rupture or tendonitis. If you develop joint, muscle, or tendon pain and swelling, you must rest, stop exercising, and seek immediate medical attention.
It is also known to rarely cause severe intestinal conditions like pseudomembranous colitis because of antibiotic-resistant bacteria. This usually happens while receiving therapy or even after treatment has stopped weeks later. During such times, do not use anti-diarrhea products or narcotics to relieve these symptoms because they may merely exacerbate them. Simply consult your doctor for the right treatment for this situation.
Avelox has the following structural formula:
• Molecular formula of avelox is C21H24FN3O4
• Chemical IUPAC Name is 1-cyclopropyl-7-[(1S,6S)-2,8-diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-4- oxo-quinoline-3-carboxylic acid
• Molecular weight is 401.431 g/mol
• Avelox available : 400mg tablets
Generic name: Moxifloxacin
Brand name(s): Moxifloxacin HCl, Vigamox
Review published on: 12 April 2009
 Your Avelox review
| .: Add date: 2009-06-19 11:01:46 |
.: Score: 1 |
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My 77 year old mother took this drug last year and called me in the midst of a panic attack that turned into thoughts of suicide before she had my father drive her to the ER. The doc told her that she had experienced a rare allergic reaction. How 'rare' is that?
Added by linda
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