Apurol, the generic name for Zyloprim, is prescribed for patients with primary or secondary gout, and those with elevated levels of serum and urinary acidic levels, such as those receiving cancer treatments for leukemia and lymphoma. It can also be used to treat patients with calcium disorders that result in high levels of daily uric acid. Apurol can be dispensed in pill form or as an injection.
The most common side effect of Apurol is a rash. These rashes can be mild to very severe, even fatal, and it is recommended that treatment with Apurol be stopped immediately if a rash develops. In addition, if an allergic reaction develops or if you experience painful or bloody peeing, you should discontinue use of Apurol. Other severe but less common side effects can include pyrexia, chills, jaundice, and either an increase or a decrease in white blood cells. In some cases, taking antibiotics at the same time as Apurol can increase the negative side effects. Other side effects can include diarrhoea, wamble or emesis, an increase in the alakaline levels in the blood, an increase in acute attacks of gout, cephalalgia, inflammation of the blood vessels, liver disorders, stomach ache, inflammation of the stomach, and upset stomach. You may also experience muscle disorders, nerve inflammation, numbness, tingling, or prickling sensations of the skin, sleepiness, nosebleeds, baldness, hives, red spots, skin sensitivity, loss or distortion of taste, kidney failure, skin edema of the tongue, loss of appetite, weakness, decreased libido, asthma, rhinorrhea, perspiration, cataracts, eye infections, impotence or male infertility. Consult your doctor if you have any of these rare reactions.
To prevent kidney stones and to help with the proper absorption of Apurol, it is important during treatment with Apurol that you drink enough water to produce two liters of urine every day. If you do not experience immediate relief of your gout, do not stop taking Apurol, since it often takes from two to six weeks to experience optimal results. It is recommended that you take your Apurol after meals in order to minimize stomach irritation.
Apurol is in Pregnancy Category C, which means that it has not been shown to cause harm to developing fetuses. However, these are results from animal studies; conclusive studies have not been done on pregnant women. It has been determined that Apurol passes into breast milk, but the effects on the nursing baby are not known. If you are pregnant or nursing, or plan to become pregnant or to nurse a baby, discuss it with your doctor to determine whether the benefits of taking Apurol outweigh any possible negative effects for you or your baby.
Apurol is rarely prescribed for children, though there are cases in which a child may have an excess of uric acid due to cancer treatments or genetic conditions. In these cases, Apurol may be indicated for pediatric use.
Apurol has the following structural formula:
• Molecular formula of apurol is C5H4N4O
• Chemical IUPAC Name is 3,5,7,8-tetrazabicyclo[4.3.0]nona-3,5,9-trien-2-one
• Molecular weight is 136.112 g/mol
• Apurol available : 100mg tablets, 300mg tablets
Generic name: Allopurinol
Brand name(s): Adenock, Ailural, Allo-Puren, Allopur, Allopurinol sodium, Allopurinolum, Allozym, Allural, Aloprim, Alopurinol, Aloral, Alositol, Aluline, Anoprolin, Anzief, Apo-Allopurinol, Apulonga, Apurin, Atisuril, Bleminol, Bloxanth, Caplenal, Cellidrin, Cosuric, Dabrosin, Dabroson, Embarin, Epidropal, Epuric, Foligan, Geapur, Gichtex, Gotax, Hamarin, Hexanuret, Ketanrift, Ketobun-A, Ledopur, Lopurin, Lysuron, Milurit, Miniplanor, Monarch, Nektrohan, Progout, Purinol, Remid, Riball, Sigapurol, Suspendol, Takanarumin, Urbol, Uricemil, Uriprim, Uripurinol, Uritas, Urobenyl, Urolit, Urosin, Urtias, Xanturat, Zyloprim, Zyloric
Review published on: 31 December 1969
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