Anhydride Arsenieux is one of the highly debatable medicaments in the medical field considering that it is poisonous to the human body. Anhydride Arsenieux was first used as a traditional Chinese medicine called Pi Shuang and is still used today to treat cancer patients and other health conditions.
Anhydride Arsenieux, which goes by the name Trisenox, is a medicament used to treat patients with leukemia that are unresponsive to other agents. This medicament was given approval for use by the U.S. Food and Drug Administration as a treatment for leukemia.
Anhydride Arsenieux is commonly administered to patients suffering from acute promyelocytic leukemia (APL) who have been unresponsive to treatment from "first-line" agents.
Anhydride Arsenieux must be diluted into intravenous solutions. 100 to 250ml of this medicament is injected to Dextrose Injection, 0.9% Sodium Chloride Injection, and USP. Keep in mind that a single-dosage is stored securely and any leftovers from the ampule must be discarded. Anhydride Arsenieux is administered 1 to 2 hours intravenously but may be extended to 4 hours if there is acute vasomotor reaction observed in the patient.
For bone marrow therapy, Anhydride Arsenieux is administered at a dosage of 0.15 mg per kg weight of the patient daily until bone marrow remission. Total dosage given to the patient should not reach 60.
Using Anhydride Arsenieux should begin 3 to 6 weeks after completing the induction therapy. It is intravenously administered 0.15 mg per kg weight of the patient daily for 25 dosages in total for 5 weeks, but may vary depending on the advice of your doctor.
Most of the patients taking Anhydride Arsenieux suffer from wamble, emesis, abdominal pains, leukocytosis, fatigue, hyperglycemia, edema, cough, rash or itching, dyspnea, cephalalgias and dizziness, and some medicament-related toxicity -- though the latter is said to be a rare case.
There were no tests conducted in regards to the interaction of Anhydride Arsenieux with other medicaments. As a safety precaution, it is advisable to consult a doctor or have them do a thorough physical and medical examination on the patient to determine the effectiveness and safety of the use of the medicament. Patients who have adverse allergic reaction to arsenic should not undergo treatment using this medicament.
Patients who are treated with Anhydride Arsenieux should be monitored at least twice a week to determine abnormalities before and after the treatment. This should be a priority for clinically unstable patients.
This medicament is in Pregnancy Category D. Any woman who is or may become pregnant should have the advice of a doctor before proceeding with the treatment. Mothers should not breastfeed their babies when under Anhydride Arsenieux treatment to avoid complications within the infant's system. People with renal and hepatic impairment should seek or consult their doctor or physician before proceeding with the treatment.
Anhydride arsenieux has the following structural formula:
• Chemical IUPAC Name is 2,4,5-trioxa-1,3-diarsabicyclo[1.1.1]pentane
• Molecular weight is 197.841 g/mol
• Anhydride arsenieux available : 10ml ampules
Generic name: Arsenic trioxide
Brand name(s): Acide arsenieux, Anhydride arsenieux, Arseni trioxydum, Arsenic blanc, Arsenic oxide, Arsenic sesquioxide, Arsenicum album, Arsenigen saure, Arsenious acid, Arsenious Oxide, Arsenious Trioxide, Arsenite, Arsenolite, Arsenous Acid, Arsenous Anhydride, Arsenous Oxide, Arsentrioxide, Arsodent, Claudelite, Claudetite, Crude Arsenic, Diarsenic Trioxide, Diarsonic Trioxide, Poison Flour, Trisenox, White Arsenic
Review published on: 20 February 2010
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