Alphatrex was originally approved by the FDA in 1961, with a foam-style formulation, called Alphatrex valerate approved in 1999. Alphatrex is a drug in the steroid family of medicaments, and comes in topical applications. Besides the foam, it can be prescribed as an ointment, cream, lotion, or aerosol spray. Its function is to reduce swelling and to decrease the body's immune response. This immune response is often what causes painful reactions that result in many different illnesses or disorders. It comes under several different brand names, including Beta-Val, Betalene, Betratrex, Diprolene, Diprosone, Maxivate, Valisone, Luxiq Foam, and Valnac Topical.
Alphatrex is used primarily to treat hormonal or endocrine disorders. In these disorders, the body does not produce its own steroids in sufficient quantity to maintain health. This can result in immune and allergic disorders and illnesses such as arthritis, lupus, psoriasis, asthma, ulcerative colitis, and granulomatous colitis. In its foam form, it can also be used for chronic itching and redness, dryness, crusting and scaling, eczema, and inflammation. All of these external manifestations are the body's immune reaction to irritations, in which the irritated areas become red, swollen, and itchy. The result can be extremely painful for the patient. Alphatrex gets inside the skin cells and decreases the inflammatory response, reducing the appearance of the reactions on the skin.
As with all medicaments, Alphatrex needs to be taken exactly as it is prescribed. Steroids are very sensitive to level of dosage and time of prescription; the amounts and frequency can also change over the duration of the prescription. If you don't understand the directions, have the doctor, nurse, or pharmacist explain the directions to you. Every dose should be taken with a full glass of water, and with food or milk, in order to avoid getting an upset stomach. Another important thing to do, if you are only taking one dose a day, is to take it before nine in the morning. If you take more than one dose, make very sure to spread them out according to the doctor's instructions. Steroid medicaments should never be abruptly stopped, and usually include a gradual reduction in dosage and frequency.
Patients who have a history of kidney illness, liver illness, high blood pressure, or heart illness, should make sure their doctor knows about these conditions before they start taking Alphatrex. Other serious conditions such as ulcerative colitis, stomach ulcers, myasthenia gravis, hypothyroidism, diabetes, or psychiatric disorder should be carefully considered before beginning a course of treatment with Alphatrex. Since Alphatrex's function is to weaken the body's immune system, people with serious bacterial, viral, or fungal infections should not use it.
Patients should also consume alcohol cautiously, since alcohol and Alphatrex can react negatively and damage the stomach. They should also avoid infections, because with the body's immune system lowered, they will be more susceptible than usual.
Some side effects of Alphatrex can be very serious. An allergic reaction, which might include difficulty breathing or swelling of the throat, lips, tongue or face, or hives is possible. Side effects could also include increased blood pressure or sudden weight gain. Consult your doctor immediately if you experience any of the above side effects. Some less serious side effects could include sleeplessness, upset stomach, lethargy, dizziness, or increased hunger or thirst.
If you accidentally use too much Alphatrex, call your local poison control center, and your doctor immediately. If someone loses consciousness or stops breathing call 911 immediately. Other more minor symptoms of an overdose might include acne, bruising, increased hair growth, high blood pressure, swollen hands, feet or ankles, and sore or weak muscles.
Alphatrex is classified in pregnancy category C, which means that its effects on a pregnant woman or unborn fetus are unknown. It is known that Alphatrex does pass into breast milk, so a nursing mother should consult a doctor if she intends to continue breastfeeding her baby.
Alphatrex has the following structural formula:
• Molecular formula of alphatrex is C22H29FO5
• Chemical IUPAC Name is 9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12, 13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• Molecular weight is 392.461 g/mol
• Alphatrex available : 0.05% cream 15gm tube, 0.05% cream 45gm tube, 0.05% lotion 60ml bottle, 0.05% ointment 15gm tube, 0.05% ointment 45gm tube, 0.1% ointment 15gm tube, 0.1% ointment 45gm tube
Generic name: Betamethasone
Brand name(s): Bebate, Becort, Bedifos, Betacorlan, Betacortril, Betaderm, Betadexamethasone, Betafluorene, Betamamallet, Betametasona, Betametasone, Betamethasonum, Betamethazone, Betapredol, Betasolon, Betatrex, Betnelan, Betsolan, Celestene, Celestone, Cidoten, Dermabet, Desacort-Beta, Diproderm, Diprolene, Diprosone, Flubenisolone, Hormezon, Lotrisone, Luxiq, Luxiqo, Maxivate, Methazon
Review published on: 09 May 2010
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