Aloprim, also known as Zyloprim, is prescribed for patients who have primary or secondary gout, and for patients with elevated levels of serum and urinary acidic levels, such as those receiving cancer treatments for leukemia and lymphoma. It can also be used to treat people who have calcium disorders that result in high levels of daily uric acid. Aloprim can be given in tablet form or as an injection.
The most common side effect of Aloprim is a skin rash. These rashes can be mild to very severe, even fatal, and it is recommended that treatment with Aloprim be stopped immediately if a rash develops. In addition, if an allergic reaction develops or if you experience painful or bloody urination, you should discontinue use of Aloprim. Severe but less common side effects can include fever, chills, jaundice, and either an increase or a decrease in white blood cells. In some cases, taking antibiotics at the same time as Aloprim can increase the negative side effects. Other side effects include diarrhea, nausea or vomiting, an increase in alakaline levels in the blood, an increase in acute attacks of gout, headache, inflammation of the blood vessels, liver disorders, abdominal pain, inflammation of the stomach, and upset stomach. You may also experience muscle disorders, nerve inflammation, numbness, tingling, or prickling sensations of the skin, sleepiness, nosebleeds, hair loss, hives, red spots, skin sensitivity, loss or distortion of taste, kidney failure, swelling of the tongue, loss of appetite, weakness, decreased libido, asthma, runny nose, sweating, cataracts, eye infections, impotence or male infertility. You should see your doctor if you have any of these rare reactions.
While taking Aloprim, it is important for you to drink enough water to produce two liters of urine every day to prevent kidney stones and to help with the absorption of Aloprim at the proper levels. If you do not experience immediate relief of your gout, do not stop taking Aloprim, since it often takes from two to six weeks to experience optimal results. Aloprim should be taken after meals in order to minimize stomach irritation.
In Pregnancy Category C, Aloprim has not been shown to cause harm to developing fetuses. However, these are results from animal studies; conclusive studies have not been done on pregnant women. It has been determined that Aloprim passes into breast milk, but the effects on the nursing baby are not known. If you are pregnant or nursing, or plan to become pregnant or to nurse a baby, you should discuss it with your doctor to determine whether the benefits of taking Aloprim outweigh any possible negative effects for you or your baby. Aloprim is rarely prescribed for children, though there are cases in which a child may have an excess of uric acid due to cancer treatments or genetic conditions. In these cases, Aloprim may be indicated for pediatric use.
Aloprim has the following structural formula:
• Molecular formula of aloprim is C5H4N4O
• Chemical IUPAC Name is 3,5,7,8-tetrazabicyclo[4.3.0]nona-3,5,9-trien-2-one
• Molecular weight is 136.112 g/mol
• Aloprim available : 100mg tablets, 300mg tablets
Generic name: Allopurinol
Brand name(s): Adenock, Ailural, Allo-Puren, Allopur, Allopurinol sodium, Allopurinolum, Allozym, Allural, Alopurinol, Aloral, Alositol, Aluline, Anoprolin, Anzief, Apo-Allopurinol, Apulonga, Apurin, Apurol, Atisuril, Bleminol, Bloxanth, Caplenal, Cellidrin, Cosuric, Dabrosin, Dabroson, Embarin, Epidropal, Epuric, Foligan, Geapur, Gichtex, Gotax, Hamarin, Hexanuret, Ketanrift, Ketobun-A, Ledopur, Lopurin, Lysuron, Milurit, Miniplanor, Monarch, Nektrohan, Progout, Purinol, Remid, Riball, Sigapurol, Suspendol, Takanarumin, Urbol, Uricemil, Uriprim, Uripurinol, Uritas, Urobenyl, Urolit, Urosin, Urtias, Xanturat, Zyloprim, Zyloric
Review published on: 31 December 1969
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